| 关 滢,冯 曼,王 璇,等.PLOD2、VSIG4在结肠癌中的表达及临床意义96例分析[J].肿瘤学杂志,2023,29(8):681-686. |
| PLOD2、VSIG4在结肠癌中的表达及临床意义96例分析 |
| Expression and Clinical Significance of PLOD2 and VSIG4 in 96 Cases with Colon Cancer |
| 投稿时间：2023-04-12 |
| DOI：10.11735/j.issn.1671-170X.2023.08.B008 |
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| 中文关键词: 结肠肿瘤 赖氨酸羟化酶2 巨噬细胞表达共刺激分子 预后 |
| 英文关键词:colon cancer procollagen-lysine 2-xoglutarate 5-dioxygenase 2 macrophages express co stimulatory molecules prognosis |
| 基金项目:山东省医药卫生科技发展计划（202103100314） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨结肠癌患者癌组织中赖氨酸羟化酶2（PLOD2）、巨噬细胞表达共刺激分子VSIG4表达及意义。［方法］ 收集经病理确认的Ⅰ～Ⅳ期结肠癌患者，应用免疫组化方法检测癌组织及其癌旁组织中的PLOD2、VSIG4表达，分析两者表达的相关性及与患者临床病理特征的关系。随访并探讨PLOD2、VSIG4表达与患者5年总生存率关系。Kaplan-Meier法绘制生存曲线，应用单因素及多因素Cox回归分析影响患者5年总生存率的因素。［结果］ 结肠癌癌组织及其癌旁组织中PLOD2表达阳性率分别为68.75%（66/96）、25.00%（24/96）（P<0.05），VSIG4表达阳性率分别为56.25%（54/96）、18.75%（18/96）（P<0.05）。Spearman相关性分析显示，结肠癌癌组织中PLOD2与VSIG4表达呈正相关（r=0.363，P=0.041）。PLOD2表达与肿瘤分化程度、浸润深度、淋巴结转移、TNM分期相关（P<0.05）；VSIG4表达与肿瘤浸润深度、淋巴结转移、TNM分期相关（P<0.05）。PLOD2阳性表达者5年总生存率为18.03%，阴性表达者为42.67%（χ2=6.969，P=0.008）；VSIG4阳性表达者5年总生存率为17.85%，阴性表达者为41.42%（χ2=9.308，P=0.002）。单因素分析结果显示：TNM分期、浸润深度、分化程度、淋巴结转移、PLOD2表达、VSIG4表达是影响患者5年总生存率的因素（P均<0.05）；多因素生存分析显示：TNM分期、PLOD2表达是影响患者5年总生存率的独立影响因素（P<0.05）。［结论］ 结肠癌患者癌组织中PLOD2、VSIG4表达均升高，两者可作为判断病情及预测预后的因素。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the expression and significance of procollagen-lysine 2-xoglutarate 5-dioxygenase 2 (PLOD2) and V-set and immunoglobulin domain-containing 4 (VSIG4) in colon cancer. ［Methods］ Samples of cancer tissue and adjacent tissues were collected from 96 patients with stage Ⅰ~Ⅳ colon cancer admitted. The expression of PLOD2 and VSIG4 was detected by immunohistochemical method， and their relationship with clinical and pathological parameters of patients was analyzed. The overall 5-year survival(OS) of patients was analyzed with Kaplan-Meier curve and the factors affecting 5-year OS of patients were examined by univariate and multivariate Cox regression analysis. ［Results］ The positive rates of PLOD2 and VSIG4 expression in colon cancer tissue and its adjacent tissues were 68.75%(66/96) and 25.00%(24/96)； 56.25%(54/96) and 18.75%(18/96)， respectively(both P<0.05). Spearman correlation analysis showed a positive correlation between PLOD2 and VSIG4 expression in colon cancer tissue(r=0.363， P=0.041). The expression of PLOD2 was correlated with the degree of differentiation， depth of infiltration， lymph node metastasis， and TNM staging(all P<0.05)， and the expression of PLOD2 was correlated with the depth of infiltration， lymph node metastasis， and TNM staging(all P<0.05). The 5-year OS of PLOD2 positive expression patients was 18.03%， while negative expression patients were 42.67%(χ2=6.969， P=0.008). The 5-year OS of VSIG4 positive expression patients was 17.85%， while that of negative expression patients was 41.42%(χ2=9.308， P=0.002). Univariate analysis showed that TNM staging， depth of infiltration， degree of differentiation， lymph node metastasis， expression of PLOD2 and VSIG4 were associated with lower 5-year OS in patients(all P<0.05). Multivariate analysis showed that TNM staging and PLOD2 expression were independent impact factors for lower 5-year OS in patients(P<0.05). ［Conclusion］ The expression of PLOD2 and VSIG4 is elevated in cancer tissues of colon cancer patients， which can serve as biomarkers for predicting prognosis of patients. |
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