| 张 倩,杨晓娟,王文欢,等.GABRP在三阴性乳腺癌中的表达及其与临床病理特征和预后的关系[J].肿瘤学杂志,2023,29(7):586-591. |
| GABRP在三阴性乳腺癌中的表达及其与临床病理特征和预后的关系 |
| Expression of GABRP in Triple-Negative Breast Cancer and Its Relationship with Clinicopathological Features and Prognosis of Patients |
| 投稿时间：2023-03-09 |
| DOI：10.11735/j.issn.1671-170X.2023.07.B007 |
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| 中文关键词: 三阴性乳腺癌 GABRP 免疫组化 生物信息学分析 生存分析 |
| 英文关键词:triple-negative breast cancer GABRP immunohistochemistry bioinformatic analysis survival analysis |
| 基金项目:2020年昆医联合专项（202001AY070001-241）；2021年昆明医科大学研究生创新基金（2021S256） |
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| 中文摘要: |
| 摘 要：［目的］ 探索三阴性乳腺癌（triple-negative breast cancer，TNBC）组织中γ-氨基丁酸A受体π亚基（gamma-aminobutyric acid type A receptor subunit pi，GABRP）的表达水平与患者临床病理资料、化疗疗效和预后的关系。［方法］ 利用 Omicsnet 数据库分析 GABRP在乳腺癌中的表达情况并分析其与临床病理特征的关系。收集2014年1月至2020年12月132例患者的临床病理资料，应用免疫组化检测132例标本中GABRP的表达情况。卡方检验分析GABRP表达与临床病理因素和化疗疗效的关系。Kaplan-Meier曲线分析GABRP表达与TNBC患者预后的关系。［结果］ 生物信息学分析发现GABRP在TNBC中高表达；GABRP表达水平与乳腺癌ER、PR、HER2、组织学分级、TP53突变、年龄、月经情况显著性相关（P＜0.05）。在132例TNBC病例中，GABRP表达与临床分期、T分期、流产史显著性相关。GABRP表达与新辅助化疗后患者的病理学疗效不相关（P＞0.05），但与临床疗效显著性相关（P＜0.05）；GABRP高表达的患者预后更差（P＜0.05）。［结论］ GABRP在TNBC中高表达，高表达的GABRP与TNBC患者的不良预后密切相关。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the expression of γ-aminobutyric acid gamma-aminobutyric acid type A receptor subunit pi(GABRP) in triple-negative breast cancer(TNBC) and its relation with clinicopathological features，chemotherapy efficacy and prognosis of patients. ［Methods］ The expression of GABRP in breast cancer was examined using the Omicsnet database， and its relationship with clinical and pathological characteristics of patients was analyzed. The expression of GABRP in 132 patients with TNBC who were admitted from January 2014 to December 2020， were detected by immunohistochemical method. The relationship of the GABRP expression with clinicopathological features and chemotherapy efficacy was analyzed. Kaplan-Meier curve was used for analysis of prognosis in TNBC patients. ［Results］ Bioinformatics analysis showed that GABRP was highly expressed in TNBC， and the expression level of GABRP was significantly correlated with ER， PR， HER2， histological grade， TP53 mutation， age and menstruation status(P＜0.05). The expression of GABRP was significantly correlated with clinical stage， T stage and history of abortion. Of 132 patients with TNBC， expression of GABRP was not correlated with the pathological efficacy of patients after neoadjuvant chemotherapy(P＞0.05)， but was significantly correlated with the clinical efficacy(P＜0.05). Survival analysis showed that in TNBC patients with high expression of GABRP had a worse prognosis(P＜0.05). ［Conclusion］ GABRP is highly expressed in TNBC， and the high expression of GABRP is closely related to the poor prognosis of TNBC patients. |
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