张露娟,刘全忠,闫 乐.miR-34家族在消化系统肿瘤中的研究进展[J].肿瘤学杂志,2023,29(6):519-524. |
miR-34家族在消化系统肿瘤中的研究进展 |
Research Progress on the Role of miR-34 Family in Digestive System Tumors |
投稿时间:2022-11-18 |
DOI:10.11735/j.issn.1671-170X.2023.06.B011 |
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中文关键词: miR-34 消化系统肿瘤 P53 预后 |
英文关键词:miR-34 digestive system tumor P53 prognosis |
基金项目:河南省中医药科学研究专项课题(2019JDZX2069) |
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中文摘要: |
摘 要:消化系统肿瘤恶性程度高,死亡率高,亟需探索新的诊治、改善预后手段。miR-34家族(miR-34a、miR-34b、miR-34c)功能众多,可以影响消化系统肿瘤细胞的侵袭、迁移、凋亡、增殖等过程,并与消化系统肿瘤的发病风险及预后有关。其中miR-34a较miR-34b、miR-34c在消化系统肿瘤中作用更广泛,miR-34家族在结直肠癌中的作用更为全面。全文概述miR-34家族在主要消化系统肿瘤中的作用及研究进展。 |
英文摘要: |
Abstract: Digestive system tumors are common malignant tumors with a high incidence and mortality rate. The miR-34 family(miR-34a, miR-34b, miR-34c) can affect the invasion, migration, apoptosis, proliferation and other processes of cancer cells in digestive system tumors, which are closely related to the diagnosis, treatment and prognosis of the disease; particularly, compared miR-34b and miR-34c, miR-34a plays a more extensive role in digestive system tumors, and miR-34 family plays a more comprehensive role in colorectal cancer. This paper summarizes research progress on the role of miR-34 family in main digestive system tumors. |
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