| 于明艳,王婷婷,杜鸣宇,等.基于SEER数据库的大样本人群中UICC/AJCC第8版分期鼻咽癌Ⅲ期预后分析[J].肿瘤学杂志,2023,29(6):502-510. |
| 基于SEER数据库的大样本人群中UICC/AJCC第8版分期鼻咽癌Ⅲ期预后分析 |
| Prognosis Analysis of Nasopharyngeal Carcinoma for Stage Ⅲ Based on UICC/AJCC 8th Edition Staging System in Large Sample Populations from SEER Database |
| 投稿时间：2023-03-31 |
| DOI：10.11735/j.issn.1671-170X.2023.06.B009 |
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| 中文关键词: 鼻咽癌 预后 分期 Ⅲ期 |
| 英文关键词:nasopharyngeal carcinoma prognosis staging stage Ⅲ |
| 基金项目:国家自然科学基金青年科学基金项目（8200102414） |
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| 摘要点击次数: 717 |
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| 中文摘要: |
| 摘 要：［目的］ 基于鼻咽癌第7版与第8版UICC/AJCC( Union for International Cancer Control， UICC/ American Joint Committee on Cancer， AJCC)分期，对流行病学和结局数据库(Surveillance， Epidemiology， and End Results Program，SEER)人群的预后进行回顾性分析，验证和比较两版分期系统对鼻咽癌人群，特别是Ⅲ期人群的分期效果。［方法］ 纳入SEER数据库2010—2019年鼻咽癌患者，利用Kaplan-Meier生存曲线分析总生存情况，用Log-rank检验检测组间生存差异，Cox 回归分析总生存相关预后影响因素，评价指标为风险比及P值。用时间依赖ROC曲线、AUC值评估变量对于生存结局的预测效能。［结果］ 对于总分期，第7版、第8版2年生存率AUC值分别为0.65、0.75，T分期分别为0.65、0.72，N分期分别为0.53、0.57。对于Ⅲ期人群，第7版分期组内存在生存差异（P<0.05），而第8版分期除T1N2M0与T3N1M0（P<0.05），其余亚组间总生存期差异均无统计学意义（P>0.05）。 ［结论］ 与鼻咽癌AJCC第7版相比，第8版系统总分期患者分布更均衡，总分期、T分期和N分期的2年生存预测效能较好，Ⅲ期内不同TN亚组预后风险相对差异小。 |
| 英文摘要: |
| Abstract：［Objective］ To validate and compare the effectiveness of the two versions of the staging system for the nasopharyngeal carcinoma(NPC)，a retrospective study of the population from the SEER (Surveillance，Epidemiology，and End Results Program，SEER) database based on the 7th and 8th edition of the UICC/AJCC (Union for International Cancer Control，UICC/American Joint Committee on Cancer，AJCC) staging system，especially for the stage Ⅲ population. ［Methods］ Patients with NPC from the SEER database between 2010—2019 were included. Kaplan-Meier survival curves was used to analyze overall survival，the Log-rank test was used to detect survival differences between the groups，and Cox regression was used to analyze prognostic influences associated with overall survival，while risk ratios and P values were evaluation indicators. Time-dependent ROC curves and AUC values were used to assess the predictive efficacy of the variables on survival outcomes. ［Results］ For overall staging，the 2-year survival AUC were 0.65 and 0.75 for 7th version and 8th version respectively，0.65 and 0.72 for T-staging，0.53 and 0.57 for N-staging respectively. For stage Ⅲ population，there was a survival difference within the 7th version staging group(P<0.05)，whereas 8th version staging system overall survival was not statistically different between subgroups (P>0.05) ，except for T1N2M0 and T3N1M0(P<0.05). ［Conclusion］ Compared with the 7th edition of AJCC，the 8th edition had a more balanced distribution of overall staging，better predictive efficacy of 2-year survival for overall，T and N staging，and relatively small differences in prognostic risk between different TN subgroups within stage Ⅲ. |
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