| 杜毅超,楼美清.肿瘤微环境和肿瘤标志物研究中数字空间多组学技术应用的研究进展[J].肿瘤学杂志,2023,29(5):430-433. |
| 肿瘤微环境和肿瘤标志物研究中数字空间多组学技术应用的研究进展 |
| Application of Digital Spatial Profiler in Studies of Tumor Microenvironment and Tumor Markers |
| 投稿时间：2023-02-09 |
| DOI：10.11735/j.issn.1671-170X.2023.05.B014 |
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| 中文关键词: 肿瘤微环境 肿瘤标志物 数字空间多组学 |
| 英文关键词:tumor microenvironment tumor markers Digital Spatial Profiler |
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| 中文摘要: |
| 摘 要：肿瘤的发生及进展依赖于肿瘤细胞与肿瘤微环境（tumor microenvironment，TME）之间复杂的相互作用，而TME中显著差异表达的蛋白质、细胞因子等物质可能成为预测肿瘤进展的标志物。探索TME并寻找肿瘤标志物已成为目前肿瘤免疫治疗领域的研究热点之一。数字空间多组学（Digital Spatial Profiler，DSP）作为一项新型的、基于光学与探针的空间组学技术，在TME和肿瘤标志物等的研究中表现出显著优势。全文论述DSP技术在多种肿瘤研究中的应用，总结其在分析TME和肿瘤标志物中的作用。 |
| 英文摘要: |
| Abstract： The tumorigenesis and progression depend on the complex interaction between tumor cells and tumor microenvironment (TME). The differentially expressed proteins， cytokines and other substances in TME may be used as tumor markers to predict the progression of tumors. The exploration of tumor markers in TME has become one of the hot spots in the field of tumor immunotherapy. Digital Spatial Profiler (DSP)， as a novel spatial omics based on optical and probe， has shown significant advantages in studies of TME and tumor markers. This article reviews the application of DSP in a variety of tumors and summarizes its powerful role in the analysis of TME and tumor markers. |
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