| 黄馨仪,刘 晓.环状RNA在三阴性乳腺癌中调控及临床意义的研究进展[J].肿瘤学杂志,2023,29(5):425-429. |
| 环状RNA在三阴性乳腺癌中调控及临床意义的研究进展 |
| Progress on the Regulating Effect of CircRNAs in Triple-Nega-tive Breast Cancer |
| 投稿时间：2023-03-05 |
| DOI：10.11735/j.issn.1671-170X.2023.05.B013 |
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| 中文关键词: 环状RNA 三阴性乳腺癌 药敏 代谢重编程 治疗靶点 生物标志物 |
| 英文关键词:circular RNA triple-negative breast cancer drug sensitivity metabolic reprogramming therapeutic targets biomarkers |
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| 摘要点击次数: 448 |
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| 中文摘要: |
| 摘 要：非编码RNA中的环状RNA（circular RNA，circRNA）在三阴性乳腺癌的肿瘤发生及进展中起着突出的作用。全文总结与三阴性乳腺癌相关circRNA的生物学特点及调控机制与通路，探讨其在影响药敏及调控代谢重编程中的作用，以及作为治疗靶点及生物标志物的价值，为三阴性乳腺癌临床诊断与治疗提供参考依据。 |
| 英文摘要: |
| Abstract： Circular RNAs(circRNAs)， a type of non-coding RNAs， play a prominent role in the tumorigenesis and progression of triple-negative breast cancer（TNBC）. In this paper the biological characteristics， regulatory mechanisms and pathways of circRNAs associated with TNBC are summarized. The effects of circRNAs on drug sensitivity and metabolic reprogramming， and their value as therapeutic targets and biomarkers are discussed to provide reference for the clinical diagnosis and treatment of TNBC. |
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