汪 敏,黄敏凤,池 俊,等.人表皮生长因子受体2低表达乳腺癌病理检测及其异质性研究进展[J].肿瘤学杂志,2023,29(5):420-424.
人表皮生长因子受体2低表达乳腺癌病理检测及其异质性研究进展
Research Progress on Clinical and Pathological Characteristics of HER2-Low Breast Cancer
投稿时间:2023-02-16  
DOI:10.11735/j.issn.1671-170X.2023.05.B012
中文关键词:  人表皮生长因子受体2  乳腺癌  病理检测  临床特征
英文关键词:human epidermal growth factor receptor 2  breast cancer  pathological examination  clinical features
基金项目:国家自然科学基金(82260604)
作者单位
汪 敏 赣南医学院第一临床医学院 
黄敏凤 赣南医学院第一临床医学院 
池 俊 赣南医学院第一附属医院 
邓星宇 赣南医学院第一临床医学院 
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中文摘要:
      摘 要:人表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)是乳腺癌的生物标志物之一。近年研究表明以曲妥珠单抗德鲁特康(T-DXd)、曲妥珠单抗多卡木嗪(SYD985)为代表的新型抗体药物偶联物可能使HER2低表达乳腺癌患者受益。按照目前的评分系统,HER2低表达乳腺癌患者占所有乳腺癌总数一半以上,从靶向治疗中获益的患者或可达到60%~70%。然而,HER2低表达乳腺癌是否具有独特生物学特异性的临床亚型尚有争议。
英文摘要:
      Abstract: Human epidermal growth factor receptor 2(HER2) is one of the biomarkers of breast cancer. Studies have shown that the antibody-drug conjugates(ADC) trastuzumab drutecan(T-DXd) and trastuzumab doxarxyzine(SYD985) may benefit patients with HER2-low breast cancer. HER2-low expression breast cancer account for more than half of all breast cancer, and the patients who may benefit from targeted therapy would reach 60%~70%. However, whether HER2-low breast cancer is a clinical subtype with unique biological specificity is still controversial at present.
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