金文奇,孙若洲,王荣荣,等.高级别胶质瘤患者瘤周水肿与预后及复发模式的相关性分析[J].肿瘤学杂志,2023,29(5):401-406. |
高级别胶质瘤患者瘤周水肿与预后及复发模式的相关性分析 |
Correlation of Peritumoral Edema with Prognosis and Recurrence Pattern in Patients with High-Grade Gliomas |
投稿时间:2023-02-02 |
DOI:10.11735/j.issn.1671-170X.2023.05.B009 |
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中文关键词: 高级别胶质瘤 瘤周水肿 复发 预后 |
英文关键词:high-grade glioma peritumoral edema recurrence prognosis |
基金项目:国家自然科学基金(81872192);江苏省卫生健康委员会重点项目(K2019028);江苏省科技厅社会发展重点项目(BE2019756) |
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中文摘要: |
摘 要:[目的] 探讨瘤周水肿与高级别胶质瘤(HGG)患者的预后及复发模式的相关性。[方法] 回顾性分析江苏省肿瘤医院放疗科在2017年6月至2020年12月期间收治HGG患者,评估肿瘤部位、瘤周水肿形态、范围与预后和肿瘤复发模式相关性。[结果]研究共纳入80例患者,全组患者中位无进展生存期(PFS)为11.2个月(95%CI:7.97~14.49),中位总生存期(OS)为27.0个月(95%CI:15.49~38.58)。单因素分析显示,年龄、病灶数目、肿瘤切除程度、瘤周水肿范围、O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT)基因甲基化状态、手术与放疗间隔时间是PFS的影响因素(P<0.05)。年龄、病灶数目、肿瘤切除程度、瘤周水肿范围、MGMT基因甲基化状态是OS的影响因素(P<0.05)。Cox多因素分析显示,年龄(HR=2.151,95%CI:1.07~4.30,P=0.031)、瘤周水肿范围(HR=2.631,95%CI:1.23~5.62,P=0.013)、MGMT基因甲基化状态(HR=2.347,95%CI:1.14~4.81,P=0.020)和手术与放疗间隔时间(HR=2.835,95%CI:1.30~6.17,P=0.009)是PFS独立预后因素,病灶数目(HR=2.322,95%CI:1.03~5.26,P=0.043)和瘤周水肿范围(HR=2.467,95%CI:1.07~5.67,P=0.034)是OS独立预后因素。瘤周水肿形态、范围及肿瘤部位与脑胶质瘤患者复发模式相关(P<0.05)。[结论] 瘤周水肿是HGG患者PFS及OS的独立危险因素,与复发模式具有密切相关性。瘤周水肿在治疗方案制定及预后评估方面具有潜在的应用价值。 |
英文摘要: |
Abstract: [Objective] To investigate the correlation between peritumoral edema and the prognosis of patients with high-grade gliomas(HGG). [Methods] Clinical data of 80 patients with HGG admitted to the Radiotherapy Department of Jiangsu Cancer Hospital from June 2017 to December 2020 were retrospectively analyzed. The risk factors of recurrence and prognosis of patients was analyzed. [Results] The median progression-free survival(PFS) was 11.2 months(95%CI: 7.97~14.49), the median overall survival(OS) was 27.0 months(95%CI: 15.49~38.58). Univariate analysis showed that age, number of lesions, extent of tumor resection, range of peritumoral edema, O6-methylguanine-DNA methyl trasferase(MGMT) gene methylation status, and the interval between surgery and radiotherapy were the influencing factors for PFS(P<0.05), and age, number of lesions, extent of tumor resection, range of peritumoral edema and MGMT gene methylation status were influencing factors for OS(P<0.05). Multivariate analysis showed that age(HR=2.151, 95%CI: 1.07~4.3.0, P=0.031), range of peritumoral edema(HR=2.631, 95%CI: 1.23~5.62, P=0.013), MGMT gene methylation status(HR=2.347, 95%CI: 1.14~4.81, P=0.020) and interval between surgery and radiotherapy(HR=2.835, 95%CI: 1.30~6.17, P=0.009) were independent prognostic factors for PFS. While the lesion number(HR=2.322, 95%CI: 1.03~5.26, P=0.043) and range of peritumoral edema(HR=2.467, 95%CI: 1.07~5.67, P=0.034) were independent prognostic factors for OS. The image appearance and range of peritumoral edema and tumor location are related to the recurrence pattern of glioma patients(P<0.05). [Conclusion] Peritumoral edema is an independent risk factor for PFS and OS in HGG patients, which is closely related to the recurrence pattern. |
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