陈少昀,马纯政,程新月,等.中性粒细胞胞外诱捕网与肺“炎-癌”转化及肺癌之间相关性的研究进展[J].肿瘤学杂志,2023,29(5):380-385. |
中性粒细胞胞外诱捕网与肺“炎-癌”转化及肺癌之间相关性的研究进展 |
Research Progress on Correlation of Neutrophil Extracellular Traps with Lung Inflammation-Cancer Transformation and Lung Cancer |
投稿时间:2022-04-28 |
DOI:10.11735/j.issn.1671-170X.2023.05.B006 |
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中文关键词: 中性粒细胞胞外诱捕网 肺癌 肺炎 炎-癌转化 |
英文关键词:neutrophil extracellular traps lung cancer pneumonia inflammation-cancer transformation |
基金项目:河南省科技厅(212102311118);河南省中医管理局(2022ZY1089,2022ZY2018,2021JDZX2131) |
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中文摘要: |
摘 要:肿瘤相关中性粒细胞是肿瘤微环境中浸润性免疫细胞的重要组成部分。中性粒细胞的能力之一是形成中性粒细胞胞外诱捕网(NETs)。NETs不仅能促进肺炎向肺癌的转化,还在肺癌中表达较高,加速了肺癌的增殖和转移。全文就NETs在促进“炎-癌”转化和肺癌之间的关系进行论述,为靶向NETs治疗肺癌提供了一个新的方向。 |
英文摘要: |
Abstract: Tumor-associated neutrophils are an important component of infiltrating immune cells in the tumor microenvironment. One of the abilities of neutrophils is to form neutrophil extracellular traps(NETs). Studies have shown that NETs can promote the transformation of lung inflammation to lung cancer, and NETs are highly expressed in lung cancer, accelerating the proliferation and metastasis of cancer cells. This paper reviews the relationship of NETs with lung inflammation-cancer transformation and lung cancer, and also explores the NETs as a potential target in lung cancer treatment. |
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