| 吕小立,李振妍,王利利,等.食管癌放疗联合免疫治疗的进展与挑战[J].肿瘤学杂志,2023,29(5):373-379. |
| 食管癌放疗联合免疫治疗的进展与挑战 |
| Advances and Challenges of Radiotherapy Combined with Immunotherapy for Esophageal Cancer |
| 投稿时间：2023-02-07 |
| DOI：10.11735/j.issn.1671-170X.2023.05.B005 |
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| 中文关键词: 食管癌 放射疗法 免疫疗法 免疫检查点抑制剂 |
| 英文关键词:esophageal cancer radiotherapy immunotherapy immune checkpoint inhibitors |
| 基金项目:国家重点研发计划项目（2022YFC2503700） |
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| 摘要点击次数: 441 |
| 全文下载次数: 63 |
| 中文摘要: |
| 摘 要：放疗作为标准的局部治疗，近年来相关研究发现其通过产生免疫刺激和免疫抑制作用，发挥不同的免疫调节效应。因此，放疗联合免疫治疗已被视为一种有效的癌症治疗新策略；然而，联合治疗的适用性仍存在一定争议，包括联合治疗的毒性和安全性、排序与时机、最佳剂量和分次等问题。全文总结当前放疗联合免疫治疗在食管癌治疗中的新进展，为全面了解、设计优化食管癌放疗联合免疫治疗方案提供必要的理论支撑。 |
| 英文摘要: |
| Abstract： Radiotherapy， as a standard local treatment， can produce various immune modulation effects by generating immune stimulation and suppression. The combination of radiotherapy and immunotherapy has been considered as an effective new strategy for cancer treatment. However， the applicability of combination therapy remains controversial in terms of toxicity and safety， sequencing and timing， optimal dosage and fractionation. This paper reviews the latest advances in radiotherapy combined with immunotherapy for esophageal cancer treatment， to provide a reference for novel strategies of esophageal cancer treatment. |
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