| 田 珊,徐笑红.循环肿瘤细胞在原发性肝癌中的研究进展[J].肿瘤学杂志,2023,29(4):329-334. |
| 循环肿瘤细胞在原发性肝癌中的研究进展 |
| Research Progress of Circulating Tumor Cell in Primary Liver Cancer |
| 投稿时间：2022-12-09 |
| DOI：10.11735/j.issn.1671-170X.2023.04.B012 |
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| 中文关键词: 原发性肝癌 循环肿瘤细胞 转移 诊断 预后 |
| 英文关键词:primary hepatic carcinoma circulating tumor cell metastasis diagnosis prognosis |
| 基金项目:浙江省医药卫生科技计划项目（2021KY553） |
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| 中文摘要: |
| 摘 要：原发性肝癌是消化系统常见的恶性肿瘤，发病率和死亡率较高，早期诊断及有效治疗是延长患者生存期的关键。循环肿瘤细胞（circulating tumor cell，CTC）是存在于外周血中各类肿瘤细胞的统称，在肿瘤的转移过程中起关键作用。外周血液CTC检测可作为一种新的手段，对肿瘤诊断、疗效评估和复发转移的监测进行有效补充。近年来随着PD-1/PD-L1免疫治疗的迅速发展，很多研究都已明确了CTC中PD-1/PD-L1表达在肿瘤诊断及预后中的重要价值。全文结合近期相关研究和临床试验的报道，就CTC在原发性肝癌中的研究进展作一综述。 |
| 英文摘要: |
| Abstract： Primary liver cancer is a common malignant tumor of the digestive system， with high morbidity and mortality. Early diagnosis and effective treatment are the key to prolong the survival of patients. Circulating tumor cells(CTCs) are tumor cells present in peripheral blood and play a key role in the metastasis of tumors. The detection of CTCs in peripheral blood can be used in diagnosis， treatment efficacy assessment and metastasis monitoring of malignant tumors. More recently， studies have shown that the detection of PD-1/PD-L1 is of significant value for immune checkpoint therapy. The research progress of CTC in primary liver cancer based on relevant studies and clinical trials are reviewed in this paper. |
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