| 于少博,张思源,刘斯迪,等.环状RNA脂肪非典型钙黏蛋白1在肿瘤中的表达及调控机制研究进展[J].肿瘤学杂志,2023,29(3):232-237. |
| 环状RNA脂肪非典型钙黏蛋白1在肿瘤中的表达及调控机制研究进展 |
| Research Progress on Expression and Regulatory Mechanism of Circular RNA Fat Atypical Cadherin 1 in Tumors |
| 投稿时间：2022-12-16 |
| DOI：10.11735/j.issn.1671-170X.2023.03.B011 |
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| 中文关键词: 肿瘤 环状RNA 环状RNA脂肪非典型钙黏蛋白1 调控机制 |
| 英文关键词:tumor circular RNA circular RNA fat atypical cadherin 1 regulatory mechanism |
| 基金项目:黑龙江省博士后科学基金（LBH-Q21023）；黑龙江省自然科学基金（LH2020H058）；国家自然科学基金（81602088） |
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| 中文摘要: |
| 摘 要：环状RNA（circular RNA，circRNA）是一类呈封闭环状结构的非编码RNA。circRNA不仅调控人体的生长发育，而且在肿瘤的发生发展中也发挥重要作用。环状RNA脂肪非典型钙黏蛋白1（circular RNA fat atypical cadherin 1，circ-FAT1）作为一种circRNA，能够通过多种机制和信号通路调控肿瘤细胞的恶性生物学行为，有望成为一种新的肿瘤标志物。全文对circ-FAT1在肿瘤中的生物学作用、调控机制及其与患者临床病理特征间的关系等研究进行总结，挖掘其未来在肿瘤疾病防治中的潜在应用价值。 |
| 英文摘要: |
| Abstract： Circular RNA(circRNA) is a type of non-coding RNA with a closed circular structure. The circRNA regulates human growth and development， and is also involved in the occurrence and progression of tumors. Circular RNA fat atypical cadherin 1(circ-FAT1) regulates the malignant bio-logical behaviors of tumor cells through a variety of mechanisms and signaling pathways， which may be used as a potential tumor biomarker. This review summarized the latest research progress on the biological function and regulatory mechanism of circ-FAT1， and its relationship with clinicopathologic features of patients， and discusses its potential application in the prevention and treatment of malignant diseases in the future. |
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