赵 婷,牛星鉴,张清媛.PARP抑制剂在乳腺癌治疗中的研究进展[J].肿瘤学杂志,2023,29(3):191-197.
PARP抑制剂在乳腺癌治疗中的研究进展
Research Progress on PARP Inhibitors in Breast Cancer Treatment
投稿时间:2022-11-30  
DOI:10.11735/j.issn.1671-170X.2023.03.B004
中文关键词:  PARP抑制剂  乳腺癌  乳腺癌易感基因  DNA损伤修复
英文关键词:poly ADP-ribose polymerase inhibitor  breast cancer  breast cancer susceptibility gene  repair of DNA damage
基金项目:
作者单位
赵 婷 哈尔滨医科大学附属肿瘤医院 
牛星鉴 哈尔滨医科大学附属肿瘤医院 
张清媛 哈尔滨医科大学附属肿瘤医院 
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中文摘要:
      摘 要:PARP抑制剂作为一种新型的小分子靶向药物,已经在乳腺癌中进行了广泛的研究,其单药在早期及晚期乳腺癌患者中已经显示出了可观的疗效,但长期单药应用所产生的PARP耐药无法避免。研究表明,PARP抑制剂与其他信号通路靶向药物,如免疫检查点抑制剂、PI3K/AKT通路抑制剂等药物的联合应用可能增强其肿瘤杀伤作用。全文就PARP抑制剂在早期及晚期乳腺癌中的单药及联合应用的研究进展进行综述。
英文摘要:
      Abstract: As a new type of small molecule targeted drug, poly ADP-ribose polymerase(PARP) inhibitor has been widely studied in breast cancer. Its single drug has shown considerable efficacy in early and advanced breast cancer patients, but the drug resistance caused by long-term single drug application can not be avoided. Studies have shown that the combination of PARP inhibitors with other signaling pathway targeted drugs, such as immune checkpoint inhibitors and PI3K/AKT pathway inhibitors, may enhance their tumor killing effect. This article reviews the research progress of PARP inhibitors in treatment of early and advanced breast cancer.
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