| 东贤进,高军林,苏 伟,等.基于术前MRI的纹理分析对47例肝细胞癌经动脉化疗栓塞术治疗后早期复发的预测分析[J].肿瘤学杂志,2023,29(2):140-144. |
| 基于术前MRI的纹理分析对47例肝细胞癌经动脉化疗栓塞术治疗后早期复发的预测分析 |
| Texture Analysis Based on Preoperative MRI to Predict 47 Cases of Liver Cancer Early Recurrence After Transarterial Chemoembolization |
| 投稿时间：2022-04-25 |
| DOI：10.11735/j.issn.1671-170X.2023.02.B009 |
|
 |
| 中文关键词: 肝细胞癌 MRI 纹理分析 经动脉化疗栓塞术 早期复发 熵值 |
| 英文关键词:hepatocellular carcinoma MRI texture analysis transarterial chemoembolization early recurrence entropy |
| 基金项目:青海省卫生健康委员会重点课题（2021-wjzd-06） |
|
| 摘要点击次数: 366 |
| 全文下载次数: 151 |
| 中文摘要: |
| 摘 要：［目的］ 基于术前MRI的纹理分析预测肝细胞癌（HCC）经动脉化疗栓塞术（TACE）治疗后的早期复发。［方法］ 回顾性分析2019年1月至2021年1月期间接受TACE治疗的47例 HCC患者。在TACE治疗前成像的动脉和门静脉期MR影像的每个轴向切片上手动描绘了HCC病灶上的感兴趣区域 (ROI) 以及肿瘤轮廓，并获取了常规MRI特征的纹理参数：偏度、峰度、均匀度、能量、熵值和自相关。比较早期复发和非早期复发亚组间的纹理参数。通过多变量逻辑回归分析进一步评估早期复发的预测因素。受试者工作特征曲线（ROC）评估纹理参数预测早期复发的能力。［结果］ 47例患者中，早期复发 20例（42.55%）。早期复发组的边缘不规则、动脉期瘤周强化和无包膜比例显著高于非早期复发组（P<0.05）。基于动脉期和门静脉期影像的熵值和基于动脉期影像的偏度，早期复发组与非早期复发组间有显著性差异（P<0.05）。多变量分析结果显示，偏度、熵值和动脉期瘤周强化是早期复发的独立预测因子（P=0.013、0.006和0.041）。通过偏度和熵值的组合，与偏度相比，ROC曲线下面积（AUC）显著提高至0.869（P=0.006）。［结论］ 使用TACE治疗前MRI的纹理参数（偏度+熵值）能有效预测HCC的早期复发。 |
| 英文摘要: |
| Abstract： ［Objective］ To explore the application of texture analysis(TA) based on preoperative MRI features in prediction of early recurrence(ER) in patients with hepatocellular carcinoma(HCC) after transarterial chemoembolization(TACE). ［Methods］ Clinical data of 47 consecutive HCC patients who received TACE between January 2019 and January 2021 were retrospectively analyzed. Regions of interest(ROI) on HCC lesions and tumor contours were manually delineated on each axial slice of arterial and portal venous phase MR images taken before TACE treatment. The texture parameters for conventional MRI features were acquired： skewness， peaks degree， uniformity， energy， entropy and autocorrelation. Texture parameter comparisons were performed between ER and non-early recurrence(NER) groups. Predictors of ER were further assessed by multivariate logistic regression analysis. Receiver operating characteristic(ROC) curve was used to assess the ability of texture parameters to predict ER. ［Results］ Among 47 patients， early recurrence occurred in 20 cases(42.55%). The ratio of irregular margins， perianeurysmal enhancement and non-capsule in the ER group was significantly higher than that in the NER group(P<0.05). The entropy values based on arterial and portal venous phase images and the skewness based on arterial phase images were significantly different between ER and NER groups(P<0.05). Multivariate analysis showed that skewness， entropy and perianeurysmal enhancement were identified as independent predictors of ER(P=0.013， 0.006 and 0.041). With the combination of skewness and entropy values， AUC was significantly improved to 0.869 compared to that of skewness alone(P=0.006). ［Conclusion］ The TA parameters(skewness+entropy) of MRI before TACE treatment can effectively predict the early recurrence of HCC. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |