| 陆轶伦,刘 畅,楼寒钰,等.甲状腺细针穿刺对甲状腺相关指标的影响[J].肿瘤学杂志,2023,29(2):129-133. |
| 甲状腺细针穿刺对甲状腺相关指标的影响 |
| The Effect of Thyroid Fine-Needle Aspiration on Thyroid-Relevant Indexes |
| 投稿时间：2022-10-09 |
| DOI：10.11735/j.issn.1671-170X.2023.02.B007 |
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| 中文关键词: 甲状腺细针穿刺 甲状腺球蛋白 甲状腺球蛋白抗体 甲状腺过氧化物酶抗体 BRAF V600E突变 |
| 英文关键词:thyroid fine-needle aspiration thyroglobulin thyroglobulin antibody thyroid peroxidase antibody BRAF V600E mutation |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺细针穿刺（fine-needle aspiration，FNA）对甲状腺相关指标的影响。［方法］使用SPSS 26.0软件进行非参数检验比较甲状腺FNA前后相关指标的变化。［结果］ 共纳入448例患者，男性患者甲状腺过氧化物酶抗体（thyroid peroxidase antibody，TPOAb）在穿刺后第1周增长0.63 IU/mL（P=0.013），促甲状腺素（thyroid stimulating hormone，TSH）在第5周下降27.6%（P=0.043），BRAF V600E突变组甲状腺球蛋白（thyroglobulin，Tg）在第2周升高33%（P=0.023）。具有该突变的女性Tg在第1周内升高7.1%（P=0.029），甲状腺球蛋白抗体（thyroglobulin antibody，TgAb）在穿刺后第2周内升高、第3周内降低（P<0.05），TgAb、TPOAb在5周后仍较穿刺前升高（P<0.05），无该突变的女性甲状腺相关指标不受FNA影响（P>0.05）。［结论］ 男性患者的甲状腺相关指标在行甲状腺FNA的5周后恢复至穿刺前水平。BRAF V600E突变女性患者5周后 TgAb、TPOAb仍较前升高。建议甲状腺FNA 5周后行甲状腺相关指标的血清学检验，若仍有显著变化可能与BRAF V600E突变有关。 |
| 英文摘要: |
| Abstract： ［Objective］ To explore the effect of thyroid fine-needle aspiration(FNA) on thyroid-relevant indexes. ［Methods］ This retrospective study compared thyroid-relevant indexes before and after fine-needle aspiration by SPSS 26.0. ［Results］ There were 448 qualified patients. In male patients， thyroid peroxidase antibody(TPOAb) increased to 0.63 IU/mL during the 1st week after FNA(P=0.013)， thyroid stimulating hormone (TSH) dropped by 27.6% during the 5th week(P=0.043)， the group of BRAF V600E mutation had a growth of 33% in thyroglobulin (Tg) (P=0.023). In female patients with this mutation， Tg increased by 7.1% during the 1st week after FNA (P=0.029)， thyroglobulin antibody (TgAb) rose during the 2nd week and fell during the 3rd week after FNA， the level of TgAb and TPOAb were still higher than the baseline 5 weeks after FNA (P<0.05). FNA didn’t significantly affect the thyroid-relevant indexes in female without the mutation (P>0.05). ［Conclusion］ The thyroid-relevant indexes in male recovered from thyroid FNA within 5 weeks. The level of TgAb and TPOAb in female with BRAF V600E mutation were still higher than those before FNA even after 5 weeks. The serum indexes of thyroid are recommended to be tested 5 weeks after FNA， while some of them may still change significantly because of BRAF V600E mutation. |
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