杨利姣,任军生,殷 星.衍生的中性粒细胞淋巴细胞比值和肺免疫预后指数对332例非手术老年非小细胞肺癌患者预后的影响分析[J].肿瘤学杂志,2023,29(2):111-116. |
衍生的中性粒细胞淋巴细胞比值和肺免疫预后指数对332例非手术老年非小细胞肺癌患者预后的影响分析 |
Derived Neutrophil Lymphocyte Ratio and Lung Immune Prognostic Index in Prognosis of Non-Small Cell Lung Cancer for 332 Cases of Elderly Non-Surgical Patients |
投稿时间:2022-12-20 |
DOI:10.11735/j.issn.1671-170X.2023.02.B004 |
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中文关键词: 非小细胞肺癌 中性粒细胞 淋巴细胞 肺免疫预后指数 预后 |
英文关键词:non-small cell lung cancer neutrophils lymphocytes lung immune prognostic index prognosis |
基金项目:河北省卫生健康委科研基金(20231909) |
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中文摘要: |
摘 要:[目的] 探讨衍生的中性粒细胞淋巴细胞比值(dNLR)和肺免疫预后指数(LIPI)对非手术老年非小细胞肺癌患者预后的影响。[方法] 回顾性分析332例非手术老年非小细胞肺癌患者的临床数据,分析患者治疗后5年内生存情况的影响因素。比较不同dNLR水平及不同LIPI水平患者治疗后5年内的生存情况。[结果]患者治疗前dNLR为2.49±1.31,治疗前LIPI评分:良好135例,中等162例,差35例。多因素分析结果显示:患者年龄、肿瘤分化程度、临床分期、dNLR、化疗情况、放疗情况、LIPI均为预后影响因素(P<0.05)。低dNLR水平组患者的中位生存时间为41.580个月,高dNLR水平组为33.330个月,差异有统计学意义(χ2=13.035,P<0.05)。LIPI水平良好组、中等组、差组患者中位生存时间分别为51.340个月、29.590个月和8.580个月,差异有统计学意义(χ2=373.576,P<0.05)。[结论] 治疗前的dNLR以及LIPI可影响非手术老年非小细胞肺癌患者的预后,对患者的预后预测有一定价值。 |
英文摘要: |
Abstract:[Objective] To explore the application of derived neutrophil lymphocyte ratio (dNLR) and lung immune prognostic index (LIPI) in the prognosis of non-small cell lung cancer (NSCLC) for elderly non-surgical patients. [Methods] The clinical data of 332 elderly non-surgical NSCLC patients were retrospectively analyzed. The relationship of survival of patients with dNLR, LIPI and other indicators was analyzed with multivariate regression analysis. [Results] Before treatment, the mean dNLR of patients was 2.49±1.31; LIPI scores showed the good prognosis in 135 cases, moderate in 162 cases, and poor in 35 cases. Multivariate analysis showed that gender, tumor differentiation, clinical stage, dNLR, chemotherapy, radiotherapy and LIPI were all prognostic factors (P<0.05). The median survival time of patients with low dNLR level and high dNLR level was 41.580 months and 33.330 months, respectively (χ2=13.035,P<0.05). The median survival time of patients with good, medium and poor LIPI level was 51.340 months, 29.590 months and 8.580 months respectively (χ2=373.576,P<0.05). [Conclusion] The dNLR and LIPI before treatment can predict the prognosis of elderly non-surgical NSCLC patients. |
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