姚舒洋,张 毅.循环肿瘤DNA监测早期肺癌术后微小残留病灶的研究进展[J].肿瘤学杂志,2023,29(1):66-70.
循环肿瘤DNA监测早期肺癌术后微小残留病灶的研究进展
Circulating Tumor DNA in Predicting Minimal Residual Disease of Patients with Early-Stage Non-Small Cell Lung Cancer
投稿时间:2022-05-20  
DOI:10.11735/j.issn.1671-170X.2023.01.B012
中文关键词:  非小细胞肺癌  微小残留病灶  循环肿瘤DNA  液体活检
英文关键词:non-small cell lung cancer  minimal residual disease  circulating tumor DNA  liquid biopsy
基金项目:2021年吴阶平医学基金会资助(320.6750.2021-23-4)
作者单位
姚舒洋 首都医科大学宣武医院 
张 毅 首都医科大学宣武医院 
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中文摘要:
      摘 要:循环肿瘤DNA(circulating tumor DNA,ctDNA)已经应用于监测转移性非小细胞肺癌(non-small cell lung cancer,NSCLC)的治疗。近来研究者开始关注ctDNA预测早期NSCLC患者根治术后微小残留病灶(minimal residual disease,MRD) 的价值。全文总结目前常用的ctDNA检测方法,并介绍了其在早期肺癌术后评估MRD和复发预警方面的应用进展。
英文摘要:
      Abstract: Circulating tumor DNA(ctDNA) has been widely used in monitoring efficacy of targeted therapy for metastatic non-small-cell lung cancer(NSCLC). Recent researches are focusing on the value of ctDNA in predicting minimal residual disease(MRD) of patients with early-stage cancer after treatment. This article reviews the techniques for detecting ctDNA and its application in monitoring MRD and recurrence in patients with early-stage NSCLC after radical resection.
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