| 赵 乐,张三元,王朝霞.上皮性卵巢癌化疗耐药及干预的研究进展[J].肿瘤学杂志,2023,29(1):24-27. |
| 上皮性卵巢癌化疗耐药及干预的研究进展 |
| Research Progress on Chemotherapy Resistance and Intervention in Epithelial Ovarian Cancer |
| 投稿时间：2022-11-18 |
| DOI：10.11735/j.issn.1671-170X.2023.01.B005 |
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| 中文关键词: 上皮性卵巢癌 耐药性 肿瘤治疗方案 |
| 英文关键词:epithelial ovarian cancer drug resistance antineoplastic protocols |
| 基金项目:山西省“四个一批”医学重点攻关专项（2021XM36） |
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| 摘要点击次数: 454 |
| 全文下载次数: 130 |
| 中文摘要: |
| 摘 要：目前上皮性卵巢癌的标准治疗包括肿瘤减灭术、辅助化疗及缓解后维持治疗方案，其中药物治疗至关重要，包含铂类/非铂化疗及各类靶向药物，旨在最大限度地消灭肿瘤细胞及延缓疾病进展。随着治疗周期的递增药物敏感性却逐渐下降，化疗耐药严重影响了药物疗效，涉及耐药机制包含药物摄取减少和流出增加、药物解毒增强或激活减少、作用靶点的改变及DNA修复增强、凋亡抑制、肿瘤微环境变化及免疫逃逸等。当前国内外很多研究已关注到需干预耐药来提高疗效，如针对药物的临床研究、免疫治疗和靶向疗法的探索、节拍化疗等方案。了解卵巢癌耐药机制并改善耐药、增强化疗敏感性有利于患者长期受益。 |
| 英文摘要: |
| Abstract： The current standard treatment for epithelial ovarian cancer includes maximum cytoreductive surgery， adjuvant chemotherapy， and post-remission maintenance therapy， in which drug therapy， including platinum-based/non-platinum-based chemotherapy and various targeted therapy， is critical to minimize tumor cells and delay disease progression. However， drug resistance gradually develops with the increasing treatment cycle， which seriously affects therapeutic efficacy. The involved mechanisms of drug resistance include decreased drug uptake and increased efflux， enhanced detoxification or reduced activation， changes in target and enhanced DNA repair， apoptosis inhibition， tumor microenvironment changes and immune escape， etc. At present， researches have focused on the intervention of drug resistance to improve the curative effect， through research on clinical drug use， exploration of new immunotherapy and targeted therapies， adaption of metronomic chemotherapy and other protocols. Understanding the mechanism of drug resistance will help to reduce the drug resistance and enhance chemotherapy sensitivity to benefit patients with ovarian cancer. |
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