| 饶慧婷,冯 涛,楼寒梅.免疫检查点抑制剂治疗宫颈癌的研究进展[J].肿瘤学杂志,2023,29(1):8-13. |
| 免疫检查点抑制剂治疗宫颈癌的研究进展 |
| Research Progress on Immune Checkpoint Inhibitors Therapy for Cervical Cancer |
| 投稿时间：2022-10-26 |
| DOI：10.11735/j.issn.1671-170X.2023.01.B002 |
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| 中文关键词: 免疫疗法 宫颈癌 复发 晚期 免疫检查点抑制剂 联合疗法 |
| 英文关键词:immunotherapy cervical cancer recurrence advanced immune checkpoint inhibitors combination therapy |
| 基金项目:浙江省公益技术应用社会发展项目（LGF19H160009）；浙江省医药卫生重大科技计划重点项目（WKJ-ZJ-2020） |
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| 中文摘要: |
| 摘 要：复发及转移性宫颈癌患者的预后较差，亟待更有效的治疗方法。免疫检查点抑制剂（immune checkpoint inhibitors，ICIs）是近来宫颈癌的研究热点，通过阻断免疫检查点与配体结合，重新激活T细胞来实现抗肿瘤作用，研究药物包括PD-1抑制剂、PD-L1抑制剂、CTLA-4抑制剂及双特异性抗体等。全文就不同ICIs药物作用机制以及不同联合治疗方式的临床进展进行综述，旨在为宫颈癌临床免疫药物选择提供参考。 |
| 英文摘要: |
| Abstract： Patients with recurrent and metastatic cervical cancer(R/MCC) have poor prognosis and need more effective treatment. The immune checkpoint inhibitors(ICIs) therapy achieves its anti-tumor effect by blocking the binding of immune checkpoint and ligand to reactivate T cells， using various agents including PD-1 inhibitors， PD-L1 inhibitors， CTLA-4 inhibitors and bispecific monoclonal antibodies， which is also a hot spot for treatment of cervical cancer. This article reviews the mechanism of various ICIs and the progress of their clinical application to provide a reference for the selection of ICIs in cervical cancer treatment. |
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