| 王海存,高 欣,刘广麟,等.肿瘤中F-box富含亮氨酸重复蛋白19反义RNA1的表达及调控作用研究进展[J].肿瘤学杂志,2022,28(11):951-957. |
| 肿瘤中F-box富含亮氨酸重复蛋白19反义RNA1的表达及调控作用研究进展 |
| Research Progress on Expression and Regulatory Mechanism of F-box and Leucine-rich Repeat Protein 19 Antisense RNA 1 in Tumors |
| 投稿时间：2022-07-05 |
| DOI：10.11735/j.issn.1671-170X.2022.11.B011 |
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| 中文关键词: 肿瘤 长链非编码RNA FBXL19-AS1 调控作用 |
| 英文关键词:tumors long non-coding RNA FBXL19-AS1 regulatory mechanism |
| 基金项目:黑龙江省博士后科学基金（LBH-Q21023）；黑龙江省自然科学基金（LH2020H058）；湖北陈孝平科技发展基金（CXPJJH12000002-2020015）；国家自然科学基金（81602088） |
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| 摘要点击次数: 543 |
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| 中文摘要: |
| 摘 要：长链非编码RNA（long non-coding RNA，lncRNA）是一类长度超过200个核苷酸且不具备编码蛋白能力的非编码RNA，并已成为癌症研究分子领域的重要组成部分。F-box富含亮氨酸重复蛋白19反义RNA1（F-box and leucine-rich repeat protein 19 antisense RNA 1，FBXL19-AS1）作为一种长链非编码RNA，已被发现在肝细胞癌、肺癌和结肠癌等多种人类恶性肿瘤中起着重要作用，其在多种肿瘤组织及血清中呈现异常表达，并能够通过不同机制影响肿瘤细胞的增殖、侵袭转移、抗凋亡、血管生成和上皮间质转化等恶性生物学行为。全文对FBXL19-AS1在肿瘤中的表达、作用及分子调控机制进行综述。 |
| 英文摘要: |
| Abstract： Long non-coding RNA(lncRNA) is a type of non-coding RNAs with more than 200 nucleotides in length， which has become an important part of cancer molecular research field. F-box and leucine-rich repeat protein 19 antisense RNA 1(FBXL19-AS1)， as a long non-coding RNA， has been found to play an important role in a variety of human malignant tumors， including hepatocellular carcinoma， lung cancer and colorectal cancer. FBXL19-AS1 is abnormally expressed in tumor tissues and serum， and can affect the malignant biological behaviors of tumor cells such as proliferation， invasion and metastasis， anti-apoptosis， angiogenesis and epithelial-mesenchymal transition through different mechanisms. This article reviews the expression， roles and molecular regulatory mechanism of FBXL19-AS1 in malignant tumors. |
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