| 刘俊良,秦 刚.PD-1/PD-L1抑制剂在骨肉瘤治疗中的研究进展[J].肿瘤学杂志,2022,28(11):922-926. |
| PD-1/PD-L1抑制剂在骨肉瘤治疗中的研究进展 |
| Advances of PD-１/PD-L1 Inhibitors in Treatment of Osteosarcoma |
| 投稿时间：2022-01-19 |
| DOI：10.11735/j.issn.1671-170X.2022.11.B006 |
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| 中文关键词: 免疫治疗 骨肉瘤 PD-１/PD-L1 临床研究 |
| 英文关键词:immunotherapy osteosarcoma PD-１/PD-L1 clinical study |
| 基金项目:国家自然科学基金项目(81860793)；广西自然科学基金项目（2020JJA140375） |
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| 中文摘要: |
| 摘 要：骨肉瘤作为原发于骨细胞常见的恶性肿瘤，近几十年来疗效上没有本质上的提高。近年来PD-１/PD-L1抑制剂在多种恶性肿瘤中显现出了卓越的疗效，并在多个研究中显现出对骨肉瘤的抗肿瘤活性，有望进一步改善骨肉瘤，特别是转移及复发患者的治疗效果。全文综述总结近年PD-１/PD-L1抑制剂治疗骨肉瘤的主要进展。 |
| 英文摘要: |
| Abstract： Osteosarcoma is the most common malignant tumor originating from bone cells， and its efficacy has not been substantially improved in recent decades. In recent years， PD-1/PD-L1 inhibitors have shown excellent efficacy in a variety of malignant tumors， including osteosarcoma. The efficacy of PD-1/PD-L1 inhibitors in treatment of osteosarcoma is expected to be further improved， especially in patients with metastasis and recurrence. This article reviews the main progress of PD-1/PD-L1 inhibitors in the treatment of osteosarcoma in recent years. |
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