| 谌 亮,李 倩,彭 敏,等.肿瘤微环境中T淋巴细胞代谢重编程的研究进展[J].肿瘤学杂志,2022,28(11):896-901. |
| 肿瘤微环境中T淋巴细胞代谢重编程的研究进展 |
| Research Progress on Metabolic Reprogramming of T Lymphocytes in Tumor Microenvironment |
| 投稿时间：2022-05-17 |
| DOI：10.11735/j.issn.1671-170X.2022.11.B002 |
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| 中文关键词: 肿瘤免疫 T淋巴细胞 代谢重编程 |
| 英文关键词:tumor immunity T lymphocytes metabolism reprogramming |
| 基金项目: |
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| 摘要点击次数: 463 |
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| 中文摘要: |
| 摘 要：先天性免疫系统和适应性免疫系统通过各种机制发挥抗肿瘤作用，推动了肿瘤免疫疗法的空前发展。研究表明，肿瘤微环境中的免疫细胞在增殖、分化和执行效应功能的过程中发生代谢重编程，与抗肿瘤免疫反应密切相关。众所周知，T淋巴细胞是最主要的抗肿瘤免疫细胞类型。全文主要讨论不同T淋巴细胞亚群代谢重编程途径对抗肿瘤免疫反应的影响，以及靶向效应T细胞代谢的抗肿瘤治疗策略。 |
| 英文摘要: |
| Abstract： Both innate and adaptive immune systems have established roles in antitumor effect through various mechanisms， based on which the tumor immunotherapy has been developed. Studies have shown that immune cells undergo metabolic reprogramming during the process of proliferation， differentiation， and execution of effector functions， which is closely related to their antitumor immune response. T lymphocytes are the most important types of antitumor immune cells. Herein， we will review the research progress on the metabolic reprogramming of different T cell subsets and its effect on antitumor immune response， also explore the antitumor therapeutic approaches targeting the metabolism of effector T cells. |
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