王 俊,钱 羽,冉凤鸣.非小细胞肺癌EGFR 20号外显子插入突变靶向治疗的研究进展[J].肿瘤学杂志,2022,28(9):764-773. |
非小细胞肺癌EGFR 20号外显子插入突变靶向治疗的研究进展 |
Research Progress on EGFR Exon 20 Insertions in Non-small Cell Lung Cancer |
投稿时间:2020-05-17 |
DOI:10.11735/j.issn.1671-170X.2022.09.B011 |
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中文关键词: 非小细胞肺癌 表皮生长因子受体 20号外显子插入突变 靶向治疗 |
英文关键词:non-small cell lung cancer epidermal growth factor receptor exon 20 insertions targeted therapy |
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中文摘要: |
摘 要:表皮生长因子受体20号外显子插入突变(epidermal growth factor receptor exon 20 insertions,EGFR ex20ins)是非小细胞肺癌中的一种罕见突变。由于EGFR ex20ins对EGFR-酪氨酸激酶抑制剂、化疗以及免疫治疗普遍不敏感,因此一直是临床治疗面临的难题。近年来,EGFR ex20ins靶向治疗研究进展不断,为该类患者的治疗带来新的希望。全文对EGFR ex20ins靶向治疗进展和临床研究进行综述,为临床靶向治疗提供参考。 |
英文摘要: |
Abstract: Epidermal growth factor receptor exon 20 insertion(EGFR ex20ins) is a rare mutation in non-small cell lung cancer(NSCLC), NSCLC with EGFR ex20ins is generally insensitive to EGFR-TKI targeted therapy, chemotherapy and immunotherapy, so it has always been a challenge for clinical treatment. In recent years, progress in EGFR ex20ins targeted therapy brings new hope for the treatment of these patients. This article reviews the latest progress and clinical research of EGFR ex20ins targeted therapy to provide reference for clinical treatment of NSCLC. |
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