吴天琦,赵玉哲,郭飞跃,等.细胞铁死亡及其在乳腺癌治疗中的意义[J].肿瘤学杂志,2022,28(9):720-724. |
细胞铁死亡及其在乳腺癌治疗中的意义 |
Ferroptosis and Its Significance in Treatment of Breast Cancer |
投稿时间:2022-03-13 |
DOI:10.11735/j.issn.1671-170X.2022.09.B003 |
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中文关键词: 铁死亡 乳腺癌 脂质过氧化 肿瘤耐药 治疗 |
英文关键词:ferroptosis breast cancer lipid peroxidation tumor resistance therapy |
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中文摘要: |
摘 要:铁死亡是一种独特的铁依赖性非凋亡细胞死亡形式,主要表现为细胞脂质活性氧堆积、细胞膜氧化损伤,其具有抑制肿瘤耐药性和增强抗肿瘤免疫力的特点,能够为乳腺癌治疗提供新的靶点、克服肿瘤耐药性。因此,诱导细胞铁死亡逐渐成为乳腺癌的一种新型治疗策略。全文对细胞铁死亡的特征、发生机制、铁死亡在乳腺癌治疗中的意义作一综述。 |
英文摘要: |
Abstract: Ferroptosis is a unique form of iron-dependence cell death manifested by cellular lipid reactive oxygen accumulation and cell membrane oxidative damage, which differs from apoptosis. Ferroptosis has the characteristics of inhibiting tumor resistance and enhancing anti-tumor immunity, which may become a novel therapeutic strategy for breast cancer. This article reviews the characteristics, anti-tumor mechanism of ferroptosis, as well as its potential application in the treatment of breast cancer. |
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