| 郭 睿,韩丽飞,王宝偲,等.乳腺癌分化拮抗非蛋白编码RNA表达及作用研究进展[J].肿瘤学杂志,2022,28(9):711-715. |
| 乳腺癌分化拮抗非蛋白编码RNA表达及作用研究进展 |
| Research Progress on Expression and Regulatory Mechanism of Differentiation Antagonizing Non-protein Coding RNA in Breast Cancer |
| 投稿时间：2022-07-01 |
| DOI：10.11735/j.issn.1671-170X.2022.09.B001 |
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| 中文关键词: 长链非编码RNA 分化拮抗非蛋白编码RNA 乳腺癌 |
| 英文关键词:long non-coding RNA differentiation antagonizing non-protein coding RNA breast cancer |
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| 摘要点击次数: 593 |
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| 中文摘要: |
| 摘 要：长链非编码 RNA(long non-coding RNA，lncRNA )是一种包含长于200个核苷酸序列且无法编码为蛋白的非编码RNA。已有较多研究证实lncRNA在乳腺癌中表达失调，参与乳腺癌的进展。分化拮抗非蛋白编码RNA是人类染色体4q12上编码的lncRNA，在乳腺癌中呈异常上调表达并广泛参与乳腺癌进展的多种信号通路。全文就分化拮抗非蛋白编码RNA在乳腺癌中的表达、功能及作用机制作简要综述。 |
| 英文摘要: |
| Abstract： Long non-coding RNA(lncRNA ) is the non-protein coding RNA containing more than 200 nucleotides. Many studies have confirmed that lncRNA is dysregulated in breast cancer and participate in the progression of breast cancer. Differentiation antagonizing non-protein coding RNA(DANCR) is an lncRNA encoded on human chromosome 4q 12， which is abnormally up-regulated in breast cancer and involved in various signaling pathways of breast cancer progression. This article reviews the expression， function and mechanism of differentiation antagonizing non-protein coding RNA in breast cancer. |
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