郭 睿,韩丽飞,王宝偲,等.乳腺癌分化拮抗非蛋白编码RNA表达及作用研究进展[J].肿瘤学杂志,2022,28(9):711-715.
乳腺癌分化拮抗非蛋白编码RNA表达及作用研究进展
Research Progress on Expression and Regulatory Mechanism of Differentiation Antagonizing Non-protein Coding RNA in Breast Cancer
投稿时间:2022-07-01  
DOI:10.11735/j.issn.1671-170X.2022.09.B001
中文关键词:  长链非编码RNA  分化拮抗非蛋白编码RNA  乳腺癌
英文关键词:long non-coding RNA  differentiation antagonizing non-protein coding RNA  breast cancer
基金项目:
作者单位
郭 睿 东南大学医学院外科医学系 
韩丽飞 东南大学附属中大医院 
王宝偲 东南大学附属中大医院 
张亚男 东南大学附属中大医院 
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中文摘要:
      摘 要:长链非编码 RNA(long non-coding RNA,lncRNA )是一种包含长于200个核苷酸序列且无法编码为蛋白的非编码RNA。已有较多研究证实lncRNA在乳腺癌中表达失调,参与乳腺癌的进展。分化拮抗非蛋白编码RNA是人类染色体4q12上编码的lncRNA,在乳腺癌中呈异常上调表达并广泛参与乳腺癌进展的多种信号通路。全文就分化拮抗非蛋白编码RNA在乳腺癌中的表达、功能及作用机制作简要综述。
英文摘要:
      Abstract: Long non-coding RNA(lncRNA ) is the non-protein coding RNA containing more than 200 nucleotides. Many studies have confirmed that lncRNA is dysregulated in breast cancer and participate in the progression of breast cancer. Differentiation antagonizing non-protein coding RNA(DANCR) is an lncRNA encoded on human chromosome 4q 12, which is abnormally up-regulated in breast cancer and involved in various signaling pathways of breast cancer progression. This article reviews the expression, function and mechanism of differentiation antagonizing non-protein coding RNA in breast cancer.
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