| 曹圆圆,叶先飞,阮森林.CEA、CA199和细胞形态学联合检测对281例良、恶性胸腔积液鉴别诊断的临床意义[J].肿瘤学杂志,2022,28(8):686-690. |
| CEA、CA199和细胞形态学联合检测对281例良、恶性胸腔积液鉴别诊断的临床意义 |
| Differential Diagnosis on 281 Cases of Benign and Malignant Pleural Effusion with Combined Detection of CEA， CA199 and Cytomorphology |
| 投稿时间：2022-06-26 |
| DOI：10.11735/j.issn.1671-170X.2022.08.B010 |
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| 中文关键词: 胸腔积液 CEA CA199 细胞形态学 鉴别诊断 |
| 英文关键词:pleural effusion CEA CA199 cytomorphology differential diagnosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肿瘤标志物CEA、CA199、细胞形态学联合检测在鉴别良、恶性胸腔积液中的临床意义。［方法］ 收集281例胸腔积液患者，其中恶性组149例，良性组132例。采用化学发光免疫法测定患者血清及胸腔积液中CEA和CA199水平。胸腔积液经离心、推片和瑞氏染色后进行细胞形态学检查，以鉴别胸腔积液的良、恶性，并评价CEA、CA199、细胞形态学联合检测在鉴别良、恶性胸腔积液诊断中的敏感度及特异度。［结果］ 恶性组胸腔积液CEA、CA199 水平及阳性率均高于良性组（P<0.05）；恶性组血清CEA、CA199 的检测水平均高于良性组（P<0.05)。胸腔积液CEA+CA199肿瘤标志物联合检测的敏感度、特异度及ROC曲线下面积分别为73.82%、69.7%和0.720，而胸腔积液 CEA+CA199联合细胞形态学检查的敏感度、特异度及ROC曲线下面积更优，分别为85.23%、69.7%和0.777。［结论］ 联合测定胸腔积液中 CA199、CEA水平和细胞形态学分析能提高良、恶性胸腔积液的鉴别诊断价值。 |
| 英文摘要: |
| Abstract： ［Objective］ To evaluate the application of combined detection of CEA， CA199 and cytomorphology in the differential diagnosis of benign and malignant pleural effusion(PE). ［Methods］ A total of 281 consecutive patients with PE were enrolled， including 149 patients with malignancies and 132 patients with benign diseases. Levels of CEA and CA199 in serum and PE were measured by chemiluminescence immunoassay； the cytomorphological examination of PE was performed with Wright’s staining. The sensitivity and specificity of the above indexes in the differentiation between malignant and benign PE were evaluated. ［Results］ The levels and positive rate of CEA， CA199 in serum and PE of the malignant group were significantly higher than those of the benign group(all P<0.05). The sensitivity， specificity and area under ROC curve of CEA+CA199 were 73.82%， 69.7% and 0.720， respectively， while those of the combined cytomorphology， CEA and CA199 were 85.23%， 69.7%， and 0.777， respectively. ［Conclusion］ The combined determination of CEA， CA199 and cytomorphology of PE can increase the identifying power for malignant and benign PE. |
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