| 李安东,于建平,李洪涛,等.BRAF联合TERT启动子突变与甲状腺乳头状癌淋巴结转移相关性Meta分析[J].肿瘤学杂志,2022,28(8):637-643. |
| BRAF联合TERT启动子突变与甲状腺乳头状癌淋巴结转移相关性Meta分析 |
| Meta-analysis of Correlation Between Double Mutations of BRAF and TERT and Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| 投稿时间：2022-02-09 |
| DOI：10.11735/j.issn.1671-170X.2022.08.B003 |
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| 中文关键词: 甲状腺肿瘤 淋巴结转移 BRAF TERT Meta分析 |
| 英文关键词:thyroid tumor lymph node metastasis BRAF TERT Meta-analysis |
| 基金项目:甘肃省自然科学基金（20JR5RA599，21JR11RA172）；甘肃省青年科技基金计划（21JR7RA013）；甘肃省卫生健康行业科研项目（GSWSKY2021-015） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨BRAF基因联合TERT启动子突变与甲状腺乳头状癌（papillary thyroid carcinoma，PTC）颈部淋巴结转移的相关性。［方法］通过文献管理数据库检索PubMed、Cochrane Library、Web of Science、中国生物医学文献数据库（CBM）、中国知网数据库（CNKI）、万方数据库、维普数据库，收集其中关于BRAF基因联合TERT启动子在PTC患者中表达情况及PTC临床病理特征相关的文献。采用Review Manager 5.4软件对研究结果进行Meta分析，通过异质性检验选择随机效应模型合并其效应量（RR值）及其95%置信区间（95%CI），并进行敏感性分析及发表偏移评估。［结果］ 根据纳入及排除标准，最终纳入17篇中英文文献进行Meta分析，共计病例5 660例，其中BRAF基因联合TERT启动子共同突变组343例，其他组5 317例，合并后效应量RR= 1.26（95%CI：1.07～1.48，P=0.006），排除3篇异质性较高的文献重新计算出RR=1.31（95%CI：1.16～1.48，P<0.001）。中央区淋巴结清扫数量的5篇文献进行单独分析，计算得出RR=1.31 (95%CI：1.02~1.69，P<0.05)。［结论］ BRAF和TERT启动子共突变与PTC颈部淋巴结转移呈明显正相关，两者共突变可显著提高PTC患者颈部淋巴结转移发生率，尤其中央区淋巴结。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the association between the double mutation of BRAF and TERT genes and lymph node metastasis of papillary thyroid carcinoma(PTC). ［Methods］ PubMed， Cochrane Library， Web of Science， Chinese Biomedical Literature Database(CBM)， CNKI， Wanfang database and VIP database were searched for articles related to the expression of BRAF and TERT in PTC patients and their clinicopathological characteristics. Meta-analysis was performed with Review Manager 5.4 software. The random effect model was selected by heterogeneity test to combine its effect size(RR) and 95% confidence interval(95%CI)， and sensitivity analysis and publication offset assessment were also performed. ［Results］ According to inclusion and exclusion criteria， 17 Chinese and English articles were included for Meta-analysis， in which 5 660 cases were involved including 3 43 cases with BRAF and TERT mutations. The RR of combined effect size was 1.26(95%CI： 1.07～1.48， P=0.006)； if 3 studies with high heterogeneity was excluded， the RR was 1.31(95%CI： 1.16～1.48， P<0.001). If 5 articles with dissected lymph nodes in the central region were separated， the RR was 1.31(95%CI： 1.02～1.69， P<0.05). ［Conclusion］ Double mutation of BRAF and TERT genes is positively correlated with lymph node metastasis in PTC， which significantly increases the probability of lymph node metastasis in the central region. |
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