| 白 瑜,黄 峰,晁 旭,等.代谢相关性脂肪肝病相关肝细胞癌代谢重编程的研究进展[J].肿瘤学杂志,2022,28(7):590-595. |
| 代谢相关性脂肪肝病相关肝细胞癌代谢重编程的研究进展 |
| Research Advances in Metabolic Reprogramming of Hepatocellular Carcinoma Related to Metabolic Associated Fatty Liver Disease |
| 投稿时间：2022-02-16 |
| DOI：10.11735/j.issn.1671-170X.2022.07.B011 |
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| 中文关键词: 代谢相关性脂肪肝病 肝细胞癌 代谢重编程 |
| 英文关键词:metabolic related fatty liver disease hepatocellular carcinoma metabolic reprogramming |
| 基金项目:国家自然科学基金（81774132）；陕西中医药大学学科创新团队项目（2019-YS05） |
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| 中文摘要: |
| 摘 要：肝癌是一种常见恶性肿瘤，近年来其发病率和死亡率呈下降趋势，但代谢相关性脂肪肝病相关肝细胞癌的发病率却呈上升趋势。全文主要讨论代谢相关性脂肪肝病相关肝细胞癌的形成机制，重点就三种关键细胞代谢途径（糖代谢、脂肪酸代谢和氨基酸代谢）与代谢相关性脂肪肝病相关肝细胞癌的研究现状进行分析。 |
| 英文摘要: |
| Abstract： The overall incidence and mortality rates of liver cancer have been decreased in recent years， however， the incidence rate of hepatocellular carcinoma(HCC) related to metabolic associated fatty liver disease(MAFLD) is rising. This article reviews the research advances in pathogenesis of MAFLD-HCC， and its relation with three key cellular metabolic pathways(glucose metabolism， fatty acid metabolism and amino acid metabolism) . |
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