| 王 猛,姜玉娟,周思成,等.68例结直肠癌异时性肝转移患者术后预后影响因素分析[J].肿瘤学杂志,2022,28(6):498-503. |
| 68例结直肠癌异时性肝转移患者术后预后影响因素分析 |
| Prognostic Factors of 68 Patients with Metachronous Liver Metastasis from Colorectal Cancer After Surgical Treatment |
| 投稿时间：2022-02-25 |
| DOI：10.11735/j.issn.1671-170X.2022.06.B010 |
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| 中文关键词: 结直肠癌 异时性肝转移 临床特征 预后 |
| 英文关键词:colorectal cancer metachronous liver metastases clinical features prognosis |
| 基金项目:中国癌症基金会北京希望马拉松专项基金(LC2017A19) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨异时性肝转移患者术后预后的影响因素。［方法］ 回顾性分析68 例接受手术治疗的结直肠癌异时性肝转移患者的临床资料，定期对患者进行随访，计算其生存率。采用单因素、多因素分析结直肠癌异时性肝转移患者术后的预后影响因素。［结果］ 单因素分析结果显示，T分期（T4/T2~3：HR=3.84，95%CI：1.43～10.28，P=0.007）、肿瘤大小（肿瘤直径≥ 3cm/肿瘤直径＜3 cm：HR=3.55，95%CI：1.46～8.62，P=0.005）和肿瘤数量（多发/单发：HR=4.27，95%CI：1.73～10.54，P=0.002）均与异时性肝转移患者预后相关。多因素分析显示，肝转移瘤数目(HR=3.86，95%CI：1.54～9.71，P=0.004)和转移瘤大小(HR=2.76，95%CI：1.05～7.27，P=0.040)是影响结直肠癌术后肝转移患者预后的独立危险因素。［结论］ 单发肝转移瘤和转移瘤大小＜3 cm的患者可通过切除转移瘤而获得较好的预后。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the prognostic factors of colorectal cancer patients with metachronous liver metastases after surgical treatment. ［Methods］ The clinical data of 68 patients with colorectal cancer who underwent surgical treatment and developed metachronous liver metastasis in Cancer Hospital， Chinese Academy of Medical Sciences and Peking Union Medical College during August 2014 to June 2021， were retrospectively analyzed. Patients were regularly followed up and the prognostic factors were analyzed by univariate and multivariate analysis. ［Results］ Univariate analysis showed that T stage(T4/T2～3： HR=3.84， 95%CI： 1.43~10.28， P=0.007)， size of metastatic tumor(diameter ≥3 cm vs diameter <3 cm： HR=3.55， 95%CI： 1.46~8.62， P=0.005) and number of metastases(multiple/single： HR=4.27， 95%CI： 1.73~10.54， P=0.002) were correlated with the prognosis of patients. Multivariate analysis showed that the number of metastases(HR=3.86， 95%CI： 1.54~9.71， P=0.004) and size of metastatic tumor(HR=2.76， 95%CI： 1.05~7.27， P=0.040) were independent prognostic factors for patients with liver metastases after resection of colorectal cancer. ［Conclusion］ Patients with single hepatic metastasis and the diameter of metastatic tumor <3 cm can achieve better prognosis by resection of metastases in colorectal cancer patients with metachronous liver metastases. |
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