杨 露,章平川,彭凡禹,等.初诊远处转移性鼻咽癌的诊疗研究进展[J].肿瘤学杂志,2022,28(5):416-423. |
初诊远处转移性鼻咽癌的诊疗研究进展 |
Progress on Diagnosis and Treatment of De Novo Metastatic Nasopharyngeal Carcinoma at Initial Diagnosis |
投稿时间:2022-01-18 |
DOI:10.11735/j.issn.1671-170X.2022.05.B013 |
|
|
中文关键词: 鼻咽癌 远处转移 诊断 治疗 |
英文关键词:nasopharyngeal carcinoma distant metastasis diagnosis treatment |
基金项目:医院青年专业技术人才培养经费(2017YYCJH-02) |
|
摘要点击次数: 695 |
全文下载次数: 271 |
中文摘要: |
摘 要:初诊远处转移性鼻咽癌(de novo metastatic nasopharyngeal carcinoma,de novo mNPC,dmNPC)具有高度异质性,预后存在差异。由于鼻咽癌属于放、化疗相对敏感的瘤种,其治疗策略除重视传统细胞毒类化疗、 靶向治疗、免疫治疗等全身药物控制外,鼻咽原发灶、颈部和远处转移病灶的局部放疗处理也有重要意义。目前在药物联合方案、原发灶放疗的获益人群、转移灶局部处理等问题上,还存在一定争议。全文对初诊远处转移性鼻咽癌的诊断(分子、影像学、预后)和化疗、靶向治疗、免疫治疗、原发灶放疗、转移灶处理等方面的最新进展进行综述。 |
英文摘要: |
Abstract: De novo metastatic nasopharyngeal carcinoma(de novo mNPC, dmNPC) is highly heterogeneous and its prognosis is variable. Since nasopharyngeal carcinoma is relatively sensitive to radiotherapy and chemotherapy, in addition to systemic drug control such as cytotoxic chemotherapy, targeted and immunotherapy, locoregional radiotherapy at the primary tumors, neck and distant metastatic sites is important. However, there are still some controversies regarding the drug combination regimen, the benefit populations of primary tumor locoregional radiothe-rapy, and the management of metastases. In this article, we will review recent advances in the molecular and imaging diagnosis, chemotherapy, targeted therapy, immunotherapy, primary tumor radiotherapy, and metastatic site management in de novo mNPC. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |