| 米 庄,龚展德,张小漩,等.靶向髓系抑制性细胞的药物在肿瘤治疗中的研究进展[J].肿瘤学杂志,2022,28(5):402-409. |
| 靶向髓系抑制性细胞的药物在肿瘤治疗中的研究进展 |
| Advance on Targeting Drug to Myeloid-derived Suppressor Cells for Tumor Treatment |
| 投稿时间：2021-09-14 |
| DOI：10.11735/j.issn.1671-170X.2022.05.B011 |
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| 中文关键词: 髓系抑制性细胞 药物 肿瘤治疗 |
| 英文关键词:myeloid-derived suppressor cells drugs tumor treatment |
| 基金项目:国家自然科学青年基金项目(81800031)；南华大学大学生创新创业训练计划项目(X2019152) |
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| 中文摘要: |
| 摘 要：髓系抑制性细胞(myeloid-derived suppressor cells，MDSCs)是机体在肿瘤等病理情况下髓系细胞分化发育受阻而形成的一群未成熟的髓系细胞。肿瘤微环境中的MDSCs具有较强的免疫抑制功能，并与肿瘤的发展密切相关，寻找以MDSCs为靶点的药物在肿瘤治疗中具有良好的应用前景。近年来，许多研究发现多种药物通过促进MDSCs分化、或抑制MDSCs扩增、或诱导MDSCs凋亡或减弱MDSCs的免疫抑制功能等方式抑制肿瘤的进展，这些研究为肿瘤的临床治疗提供了新策略。 |
| 英文摘要: |
| Abstract： Myeloid-derived suppressor cells(MDSCs) are a heterogeneous population of immature myeloid cells generated from the blockade of myeloid cell differentiation under pathological conditions， such as cancer. MDSCs in the tumor microenvironment have a potent immunosuppressive function and are closely correlated with tumor progression. Development of targeting drugs to MDSCs has a promising prospect for cancer immunotherapy. A variety of drugs have been found to suppress tumor progression by promoting MDSCs differentiation， inhibiting MDSCs expansion， inducing MDSCs apoptosis or dampening the immunosuppressive function of MDSCs. This article reviews the recent research advances in this aspect to provide information for developing novel strategies of cancer treatment. |
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