| 刘 固,李 兴,雷建林,等.表皮生长因子样结构域7蛋白在154例结直肠癌中的表达及其临床意义分析[J].肿瘤学杂志,2022,28(4):305-309. |
| 表皮生长因子样结构域7蛋白在154例结直肠癌中的表达及其临床意义分析 |
| Expression of Epidermal Growth Factor?鄄like Domain 7 Protein in 154 Cases with Colorectal Cancer and Its Clinical Significance |
| 投稿时间：2021-07-31 |
| DOI：10.11735/j.issn.1671-170X.2022.04.B009 |
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| 中文关键词: 结直肠癌 表皮生长因子样结构域7 临床病理特征 预后 |
| 英文关键词:colorectal cancer epidermal growth factor-like domain 7 clinicopathological characteristics prognosis |
| 基金项目:郴州市科技计划项目（ZDYF2020058） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨表皮生长因子样结构域7（epidermal growth factor-like domain 7，EGFL7）蛋白在结直肠癌（colorectal cancer，CRC）中表达及其临床意义。［方法］ 选取154例施行CRC根治术切除患者作为病例组，同时选取47名行肠镜检查的健康体检者作为健康者组，分别收集CRC组织和正常结直肠黏膜组织标本。采用免疫组织化学SP法检测CRC组织及正常结直肠黏膜组织中EGFL7蛋白的表达，分析EGFL7蛋白表达与患者临床病理特征及术后预后的关系。［结果］ CRC组织中EGFL7蛋白阳性表达率为68.2%，显著高于正常结直肠黏膜组织的31.9%（χ2=19.687，P<0.001）。EGFL7蛋白表达在不同浸润深度（χ2=6.057，P=0.014）、淋巴结转移（χ2=5.229，P=0.022）、远处转移（χ2=4.857，P=0.028）和TNM分期（χ2=8.195，P=0.004）CRC患者中的差异均有统计学意义。EGFL7蛋白阳性表达者生存率显著低于阴性表达者（χ2=7.022，P=0.008），且EGFL7阳性表达是影响CRC患者术后预后的独立危险因素（HR=3.443，95%CI：1.924~6.160，P<0.001）。［结论］ EGFL7蛋白在CRC发生和侵袭、转移的不良事件，如淋巴结转移、远处转移中呈阳性表达，且EGFL7蛋白阳性表达是CRC患者术后预后的独立危险因素，提示EGFL7有望成为一个新的CRC诊断和预后标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of epidermal growth factor-like domain 7(EGFL7) protein in colorectal cancer(CRC) and its clinical significance. ［Methods］ One hundred and fifty-four CRC patients undergoing radical resection and forty-seven healthy individuals undergoing colonoscopy biopsy(control group) were enrolled in the study. Specimens of CRC tissue and normal colorectal mucosal tissue were collected. Immunohistochemistry SP method was used to detect the expression of EGFL7 protein in CRC tissues and normal colorectal mucosal tissues， and the relationship of EGFL7 protein expression with clinical pathological characteristics and postoperative prognosis of CRC patients was analyzed. ［Results］ The positive expression rate of EGFL7 protein in CRC tissue was 68.2%， which was significantly higher than that in normal colorectal mucosa(31.9%)(χ2=19.687， P<0.001). The EGFL7 protein expression was associated with tumor invasion(χ2=6.057， P=0.014)， lymph node metastasis(χ2=5.229， P=0.022)， distant metastasis(χ2=4.857， P=0.028)， and TNM stage group(χ2=8.195， P=0.004). The survival rate of CRC patients with positive expression of EGFL7 protein was significantly lower than those with negative expression(χ2=7.022， P=0.008). Positive expression of EGFL7 protein was an independent risk factor for postoperative prognosis of CRC patients(HR=3.443， 95%CI： 1.924~6.160， P<0.001). ［Conclusion］ The up-regulated expression of EGFL7 protein is associated with lymph node metastasis， distant metastasis， and poorer postoperative prognosis of CRC patients， indicating that EGFL7 may be a potential diagnostic and prognostic marker for CRC. |
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