| 范 东,葛萍萍,吴 琼,等.外周血NLR和PLR在胃癌中的研究进展[J].肿瘤学杂志,2022,28(4):291-297. |
| 外周血NLR和PLR在胃癌中的研究进展 |
| Research Progress on Peripheral Blood Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Gastric Cancer |
| 投稿时间：2022-01-25 |
| DOI：10.11735/j.issn.1671-170X.2022.04.B007 |
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| 中文关键词: 胃癌 中性粒细胞与淋巴细胞比值 血小板与淋巴细胞比值 诊断 治疗 预后 |
| 英文关键词:gastric cancer neutrophil to lymphocyte ratio platelet to lymphocyte ratio diagnosis, treatment prognosis |
| 基金项目: |
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| 摘要点击次数: 508 |
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| 中文摘要: |
| 摘 要：胃癌发病率较高，许多患者确诊时已为晚期，预后差。早期诊断、加强可切除患者的围手术期管理、针对晚期患者选择合适的综合治疗方案等措施能改善胃癌患者的预后。炎症在肿瘤发生发展中扮演着重要角色，外周血炎性指标可间接反映机体与肿瘤之间的相互作用，且因其易获取、重复性好、廉价等优势，近年来外周血炎性指标与恶性肿瘤的相关性得到广泛研究，其中最具代表性的是中性粒细胞与淋巴细胞比值（neutrophil to lymphocyte ratio，NLR）和血小板与淋巴细胞比值（platelet to lymphocyte ratio，PLR）。NLR和PLR与胃癌的相关性研究已在各个阶段展开，全文就其在胃癌诊断、治疗、预后中的临床作用进行综述。 |
| 英文摘要: |
| Abstract： The incidence rate of gastric cancer is high. Many patients have a poor prognosis because they are diagnosed at an advanced stage. Therefore， early diagnosis， strengthening perioperative mana-gement for patients with resectable tumors， and selecting appropriate comprehensive treatment for advanced patients can improve the prognosis of gastric cancer. It is well known that inflammation plays an important role in the occurrence and development of neoplasms， and peripheral inflammation indexes can indirectly reflect the interaction between the body and neoplasms. Due to the advantages of easy acquisition， good repeatability and low costs， the correlation between peripheral blood inflammatory indicators and malignant tumors has been widely studied in recent years， among which the most representative ones are neutrophil to lymphocyte ratio(NLR) and platelet to lymphocyte ratio(PLR). Studies on the correlation between NLR and PLR and gastric cancer have been carried out in various stages. This article will review the clinical roles of NLR and PLR in the diagnosis， treatment and prognosis of gastric cancer. |
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