| 吴 越,闫亮亮,黎海亮,等.动态增强MRI定量参数与可切除胃腺癌T、N分期的相关性分析[J].肿瘤学杂志,2022,28(4):285-290. |
| 动态增强MRI定量参数与可切除胃腺癌T、N分期的相关性分析 |
| Relationship of Quantitative Dynamic Contrast-Enhanced MRI Parameters with T and N Staging of Resectable Gastric Adenocarcinoma |
| 投稿时间：2022-03-04 |
| DOI：10.11735/j.issn.1671-170X.2022.04.B006 |
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| 中文关键词: 胃腺癌 动态增强磁共振成像 定量DCE参数 T分期 N分期 |
| 英文关键词:gastric adenocarcinoma dynamic contrast-enhanced magnetic resonance imaging quantitative DCE parameters T stage N stage |
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| 中文摘要: |
| 摘 要：［目的］ 探讨动态增强磁共振成像（DCE-MRI）定量DCE参数与胃腺癌T、N分期的相关性。［方法］ 纳入河南省肿瘤医院2019年1月至2021年9月行DCE-MRI检查的胃腺癌患者88例，采用Spearman秩相关分析评价定量DCE参数Ktrans、Kep、Ve与胃腺癌T、N分期的相关性。对上述差异有统计学意义的参数绘制ROC曲线以明确鉴别胃腺癌T、N分期的最佳诊断参数及诊断效能。［结果］ 定量DCE参数Ktrans、Kep、Ve与T分期间呈正相关（r=0.597、0.510、0.476，P均<0.001）。ROC分析表明Ve是鉴别胃腺癌T分期的最佳参数，其AUC值为0.924，灵敏度和特异度分别为100.0%、83.5%。Ktrans与N分期间呈正相关（r=0.276，P=0.009）。Ktrans鉴别N分期的AUC值为0.574，灵敏度和特异度分别为47.8%、76.9%。［结论］ 定量DCE参数与胃腺癌T、N分期存在一定相关性，可能为从DCE-MRI方面评估胃腺癌的生物学行为、恶性程度及治疗方案的选择等提供了理论依据。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the correlation of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) parameters with T and N staging of gastric adenocarcinoma. ［Methods］ Eighty-eight patients with gastric adenocarcinoma who underwent DCE-MRI examination in Henan Cancer Hospital from January 2019 to September 2021 were enrolled. Spearman rank correlation analysis was used to evaluate the correlation of quantitative DCE parameters Ktrans， Kep， Ve with T and N staging of gastric adenocarcinoma. ROC analysis were performed for the above parameters with statistically significant differences to determine the best diagnostic parameters and their diagnostic performance for T and N staging of gastric adenocarcinoma. ［Results］ Quantitative DCE parameters Ktrans， Kep， Ve were positively correlated with T staging(r=0.597， 0.510， 0.476， all P<0.001)， and ROC analysis showed that Ve was the best parameter to diagnose T staging of gastric adenocarcinoma， the AUC value was 0.924， and the sensitivity and specificity were 100.0% and 83.5%， respectively. Ktrans was positively correlated with N staging(r=0.276， P=0.009)， and the AUC value of Ktrans to determine N staging was 0.574， and the sensitivity and specificity were 47.8% and 76.9%， respectively. ［Conclusion］ The quantitative DCE parameters are correlated with T and N staging of gastric adenocarcinoma， indicating that DCE-MRI may be used to evaluate the biological behavior， malignant degree and treatment options of gastric adenocarcinoma. |
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