| 臧志意,魏小东,赵海滨.膜穿孔蛋白D及VEGF表达在肺腺癌中的临床意义及对血管生成的影响[J].肿瘤学杂志,2022,28(3):197-203. |
| 膜穿孔蛋白D及VEGF表达在肺腺癌中的临床意义及对血管生成的影响 |
| Clinical Significance of Gasdermin-D and VEGF Expression in Lung Adenocarcinoma and Their Relation with Angiogenesis |
| 投稿时间：2021-07-02 |
| DOI：10.11735/j.issn.1671-170X.2022.03.B007 |
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| 中文关键词: 肺腺癌 膜穿孔蛋白D 血管内皮生长因子 预后 影响因素 |
| 英文关键词:lung adenocarcinoma gasdermin-D vascular endothelial growth factor prognosis influencing factors |
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| 中文摘要: |
| 摘 要：［目的］探究膜穿孔蛋白D（gasdermin-D，GSDMD）、血管内皮生长因子（vascular endothelial growth factor，VEGF）在肺腺癌中表达的临床意义以及对血管生成的影响。［方法］ 收集中国人民解放军联勤保障部队第九〇四医院胸外科2014年1月至2017年1月进行手术诊治的80例肺腺癌患者的临床病理资料。免疫组化检测肺腺癌组织与相应癌旁组织中的GSDMD、VEGF表达及MVD计数（CD34标记），并计算高表达率，分析GSDMD及VEGF表达与预后的关系以及对血管生成的影响。［结果］肺腺癌组织中GSDMD、VEGF表达水平及MVD计数明显高于癌旁组织（P＜0.05）。肺腺癌中GSDMD及VEGF表达与MVD计数之间呈正相关（P＜0.05）。单因素分析提示分化程度、肿块直径、淋巴结转移、TNM分期、GSDMD及VEGF表达水平影响患者的预后（P＜0.05），Cox多因素生存分析提示GSDMD高表达（HR=1.957， 95%CI：1.022~3.748，P＜0.05）及VEGF高表达（HR=2.367，95%CI：1.236~4.532，P＜0.05）是影响患者生存的独立危险因素；而分化程度（HR=0.521，95%CI：0.291~0.932，P＜0.05）是影响患者生存的独立保护因素。［结论］GSDMD及VEGF在肺腺癌中高表达，可能通过促进肿瘤血管生成加速肿瘤的进展，导致患者预后不良，并且两者是影响肺腺癌患者预后的独立危险因素。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the clinical significance of gasdermin-D(GSDMD) and vascular endothelial growth factor(VEGF) expression in lung adenocarcinoma and their relation with angiogenesis. ［Methods］ The clinicopathological data of 80 patients with lung adenocarcinoma admitted in the Department of Thoracic Surgery of the 904th Hospital from January 2014 to January 2017 were collected. The expression of GSDMD， VEGF and CD34(marker of microvessel density， MVD) in lung adenocarcinoma tissue and corresponding adjacent tissues were detected by immunohistochemistry， and the relationship of GSDMD and VEGF expression with tumor angiogenesis and prognosis of patients was analyzed. ［Results］ The expression rate of GSDMD， VEGF and MVD count in the lung adenocarcinoma group were significantly higher than those in the adjacent tissues(P＜0.05). The expression of GSDMD and VEGF were positively correlated with the count of MVD in lung adenocarcinoma(P＜0.05). Univariate analysis showed that the degree of differentiation， tumor diameter， lymphatic metastasis， TNM stage， GSDMD and VEGF expression levels were significantly associated with the survival of patients(P<0.05). Cox multivariate analysis suggested that high expression of GSDMD(HR=1.957， 95%CI：1.022~3.748， P＜0.05) and high expression of VEGF(HR=2.367， 95%CI：1.236~4.532， P＜0.05) were the independent risk factors for the survival of patients， the degree of differentiation(HR=0.521， 95%CI：0.291~0.932， P＜0.05) was an independent protective factor for the survival of patients. ［Conclusion］ GSDMD and VEGF are highly expressed in lung adenocarcinoma， which may accelerate tumor progression by promoting tumor angiogenesis， leading to poor prognosis of patients. |
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