| 张璐宁,谢长生.恶性肿瘤免疫相关血小板减少的发生机制及中西医治疗对策[J].肿瘤学杂志,2022,28(3):191-196. |
| 恶性肿瘤免疫相关血小板减少的发生机制及中西医治疗对策 |
| The Pathogenesis of Immune-related Thrombocytopenia on Malignant Tumors and the Treatment Strategies of Traditional Chinese and Western Medicine |
| 投稿时间：2022-01-23 |
| DOI：10.11735/j.issn.1671-170X.2022.03.B006 |
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| 中文关键词: 恶性肿瘤 免疫检查点抑制剂 免疫相关血小板减少 发病机制 中西医治疗 |
| 英文关键词:malignant tumor immune checkpoint inhibitors immune-related thrombocytopenia pathogenesis traditional Chinese and western medicine |
| 基金项目:国家自然科学基金（81774233） |
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| 摘要点击次数: 752 |
| 全文下载次数: 228 |
| 中文摘要: |
| 摘 要：免疫相关血小板减少作为免疫检查点抑制剂的不良反应之一，对患者的抗肿瘤治疗产生较大影响，且存在一定死亡风险。目前免疫相关血小板减少的发病机制、诊断标准及治疗方法尚未完全明确，临床治疗上多以类固醇作为常用的基础药物，中医辨证施治以“治火、治气、治血”为主要治则。全文综述近年来免疫相关血小板减少的发病情况、发生机制、管理与诊断、治疗，以期实现早期诊断并专业的治疗，使患者在保证生活质量的前提下，拥有更长生存期。 |
| 英文摘要: |
| Abstract： As one of the adverse reactions of immune checkpoint inhibitors， immune-related thrombocytopenia has a great impact on the anti-tumor treatment of patients， and there is a certain risk of death. At present， the pathogenesis， diagnosis and treatment of immune-related thrombocytopenia have not been fully clari-fied. In clinical treatment， steroids are mostly used common and basic drugs. The main principles of traditional Chinese medicine syndrome differentiation and treatment are“control of fire， Qi and blood”. This paper reviews the incidence， mechanism， management， diagnosis， and treatment of immune-related thrombocytopenia in recent years， with a view to realize earlier diagnosis and professional treatment， so that patients can have a longer survival period on the premise of ensuring the quality of life. |
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