孙强强,宗 丹,钱普东.室管膜下区神经干细胞的恶性转化与胶质母细胞瘤发生发展的研究进展[J].肿瘤学杂志,2022,28(2):138-144. |
室管膜下区神经干细胞的恶性转化与胶质母细胞瘤发生发展的研究进展 |
Research Advances on Malignant Transformation of Neural Stem Cells in Subventricular Zone in Glioblastoma Development |
投稿时间:2021-10-14 |
DOI:10.11735/j.issn.1671-170X.2022.02.B011 |
|
|
中文关键词: 胶质母细胞瘤 室管膜下区 神经干细胞 胶质瘤干细胞 |
英文关键词:glioblastoma subventricular zone neural stem cells glioblastoma stem cells |
基金项目:国家自然科学基金项目(81872192);江苏省卫生健康委员会重点项目(K2019028);江苏省科技厅社会发展重点项目(BE2019756) |
|
摘要点击次数: 926 |
全文下载次数: 265 |
中文摘要: |
摘 要:胶质母细胞瘤(glioblastoma,GBM)是原发性中枢神经系统肿瘤中最具侵袭性的恶性肿瘤。GBM标准治疗包括尽可能的手术切除与辅以放、化疗为主的综合治疗。室管膜下区(subventricular zone, SVZ)含有大量的神经干细胞,可恶性转化为胶质瘤干细胞,与肿瘤的发生、增殖、治疗抵抗和复发关系密切。全文就室管膜下区神经干细胞与GBM中的胶质瘤干细胞之间的关系,以及室管膜下区治疗进展作一综述。 |
英文摘要: |
Abstract: Glioblastoma(GBM) is the most aggressive malignant tumor in primary central nervous system tumors. Currently, the newly diagnosed GBM standard treatment includes surgical resection as far as possible and combining with radiotherapy and chemotherapy. The subventricular zone contains a large number of neural stem cells(NSC), which can be malignantly transformed into glioma stem cells(GSC), is closely related to tumor occurrence, proliferation, treatment resistance and recurrence. This article reviews the relationship between NSC and GSC and advances in treatment of the subventricular zone. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |