| 郝婷婷,申 妮,张 锦.结直肠癌患者微创根治手术后淋巴结检出影响因素及纳米碳示踪应用价值分析[J].肿瘤学杂志,2022,28(2):117-121. |
| 结直肠癌患者微创根治手术后淋巴结检出影响因素及纳米碳示踪应用价值分析 |
| Influencing Factors of Lymph Node Detection After Minimally Invasive Radical Surgery in Patients with Colorectal Cancer and the Application Value of Nano Carbon Tracing |
| 投稿时间：2021-08-26 |
| DOI：10.11735/j.issn.1671-170X.2022.02.B007 |
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| 中文关键词: 结直肠癌 手术 淋巴结 纳米碳 |
| 英文关键词:colorectal cancer surgery lymph node nano carbon |
| 基金项目:延安大学附属医院院内培育基金(2021PT-14) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨结直肠癌（colorectal cancer，CRC）患者微创根治手术后淋巴结检出的影响因素及纳米碳示踪应用价值。［方法］ 纳入行微创根治手术治疗CRC患者672例，根据是否采用纳米碳示踪分组，通过倾向评分法完成基线资料匹配，采用单因素和多因素法评价微创根治手术后淋巴结及阳性淋巴结检出数量独立影响因素。［结果］ ①倾向性评分匹配后示踪组与非示踪组患者各37例；两组基线资料比较差异无统计学意义（P>0.05）；示踪组检出阳性淋巴结数量显著多于非示踪组（P<0.05）。②单因素分析结果显示，性别、病灶位置、肿瘤最大径及是否行纳米碳示踪均与微创根治手术后淋巴结检出数量有关（P<0.05）；多因素分析结果显示，病灶位置和是否行纳米碳示踪均是微创根治手术后淋巴结检出数量独立影响因素（P均<0.05）。③病理类型、T分期、病理组织学分级、神经侵犯情况及是否合并癌结节均与微创根治手术后阳性淋巴结检出数量有关（P<0.05）；多因素分析结果显示，T分期、病理组织学分级、脉管侵犯及合并癌结节情况均是微创根治手术后阳性淋巴结检出数量独立影响因素（P<0.05）。［结论］ CRC患者微创根治手术后淋巴结检出数量与病灶位置和是否行纳米碳示踪关系密切；T2~4期、组织学分级3~4级、合并脉管侵犯及癌结节者更易检出阳性淋巴结。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer(CRC) and the application value of nano carbon tracing. ［Methods］ Six hundred and seventy-two CRC patients underwent minimally invasive radical surgery. Thirty seven pairs of patients with or without application of nano carbon tracer were matched by propensity scoring method， and included in the study. Univariate and multivariate regression analyses were used to evaluate the independent influencing factors of the number of lymph nodes and positive lymph nodes after minimally invasive radical surgery. ［Results］ There was no significant difference in baseline data between 2 groups（P>0.05）. Univariate analysis showed that gender， age， lesion location， maximum tumor diameter and whether nano carbon tracing was performed were related to the number of lymph nodes detected after minimally invasive radical surgery(P<0.05). Multivariate analysis showed that the location of lesions and nano carbon tracing were independent influencing factors of number of lymph nodes after minimally invasive radical surgery(P<0.05). Univariate analysis showed that the pathological type， T stage， histopathological grade， vascular invasion， nerve invasion and cancer nodules were related to the number of positive lymph nodes after minimally invasive radical surgery（P<0.05）. Multivariate analysis showed that T stage， histopathological grade， vascular invasion and cancer nodules were independent factors related to the number of positive lymph nodes after minimally invasive radical surgery（P<0.05）. ［Conclusion］ The lymph nodes number detected after minimally invasive radical surgery in CRC patients is closely related to the location of lesions and whether nano carbon tracing is performed. Positive lymph nodes were more likely to be detected in T2~4 stage， histological grade 3~4， combined with vascular invasion and cancer nodules. The application of nano carbon tracing is helpful to detect more lymph nodes， but its value in improving the detection of positive lymph nodes remains to be confirmed. |
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