| 赵威威,原 娜,陈安祺.高迁移率族蛋白B-1在直肠癌中的表达及其与ZO-1、Occludin、TNF-α、IFN-γ的相关性分析[J].肿瘤学杂志,2022,28(2):111-116. |
| 高迁移率族蛋白B-1在直肠癌中的表达及其与ZO-1、Occludin、TNF-α、IFN-γ的相关性分析 |
| Expression of HMGB-1 in Rectal Cancer and Its Relationship with ZO-1， Occludin， TNF-α and IFN-γ |
| 投稿时间：2021-08-09 |
| DOI：10.11735/j.issn.1671-170X.2022.02.B006 |
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| 中文关键词: 直肠癌 高迁移率族蛋白B-1 肠黏膜屏障 闭合蛋白 紧密连接蛋白 肿瘤坏死因子-α 干扰素-γ |
| 英文关键词:rectal cancer high mobility group protein B-1 zonula occludens-1 occluding protein tight junction protein tumor necrosis factor-α interferon gamma |
| 基金项目:河北省政府资助临床医学优秀人才培养项目计划 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨高迁移率族蛋白B-1（HMGB-1）在直肠癌中的表达及其对肠黏膜屏障、炎性因子的影响。［方法］ 通过免疫组织化学法检测并分析110例Ⅰ～Ⅲ期直肠癌患者中HMGB-1的表达，及其与临床病理特征、预后的关系。采用免疫组化检测并分析HMGB-1与紧密连接蛋白（ZO-1）、闭合蛋白（Occludin）、肿瘤坏死因子-α（TNF-α）、干扰素-γ（IFN-γ）的关系。［结果］ 110例直肠癌患者中，HMGB-1阳性表达率为66.4%，阴性表达率为33.6%。HMGB-1表达与直肠癌患者分化程度、淋巴结转移、脉管癌栓和TNM分期有关（P＜0.05）；而与性别、年龄、肿瘤直径和神经受侵无关（P＞0.05）。Cox回归分析提示HMGB-1（HR=0.437，95%CI：0.202～0.947，P=0.036）和脉管癌栓（HR=0.461，95%CI：0.233～0.912，P=0.026）是直肠癌患者预后不良的独立危险因素。HMGB-1阳性与阴性患者的5年生存率分别为 45.2％和78.4％，差异有统计学意义（P=0.003）。HMGB-1与ZO-1、Occludin的表达呈负相关（r=-0.202，P=0.034；r=-0.287，P=0.003），与TNF-α、IFN-γ的表达呈正相关（r=0.232，P=0.015；r=0.327，P=0.001）。［结论］ 高表达HMGB-1的直肠癌患者生存期明显缩短，可能与肠黏膜屏障的损害及炎性因子TNF-α、IFN-γ的产生有关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of high mobility group protein B-1(HMGB-1) in rectal cancer and its relationship with clinicopathological features and the prognosis of patients. ［Methods］ The expression of HMGB-1 was detected with immunohistochemistry in 110 patients with stage I～Ⅲ rectal cancer， and its relationship with clinicopathological characteristics and prognosis of patients was analyzed. The correlation of HMGB-1 expression with zonula occludens-1(ZO-1)， occluding protein(Occludin)， tumor necrosis factor-α(TNF-α)， interferon gamma(IFN-γ) was also analyzed. ［Results］ Among 110 patients with rectal cancer， the positive and negative rates of HMGB-1 were 66.4% and 33.6%， respectively. The expression of HMGB-1 was correlated with tumor differentiation， lymph node metastasis， vascular tumor thrombus and TNM staging in patients with rectal cancer(all P＜0.05)； while was not correlated with gender， age， tumor diameter and nerve invasion(all P＞0.05). Cox regression analysis indicated that HMGB-1(HR=0.437， 95%CI： 0.202～0.947， P=0.036) and vascular tumor thrombus(HR=0.461， 95%CI： 0.233～0.912， P=0.026) were independent risk factors for poor prognosis in rectal cancer patients. The 5-year overall survive(OS) of HMGB-1 positive and negative patients was 45.2% and 78.4%， respectively(P=0.003). HMGB-1 expression was negatively correlated with ZO-1 and Occludin(r=-0.202， P=0.034； r=-0.287， P=0.003)， and positively correlated with TNF-α and IFN-γ(r=0.232； P=0.015； r=0.327， P=0.001). ［Conclusion］ The survival of rectal cancer patients with the higher expression of HMGB-1 is significantly reduced， which may be related to the damage of intestinal mucosa and the production of TNF-α and IFN-γ. |
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