| 孙 瑞,王 超,李 宁.241例非小细胞肺癌并发导管相关上肢静脉血栓的危险因素分析[J].肿瘤学杂志,2022,28(1):35-39. |
| 241例非小细胞肺癌并发导管相关上肢静脉血栓的危险因素分析 |
| Risk Factors of Catheter-related Upper Extremity Venous Thrombosis in 241 Patients with Non-small Cell Lung Cancer |
| 投稿时间：2021-08-07 |
| DOI：10.11735/j.issn.1671-170X.2022.01.B007 |
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| 中文关键词: 非小细胞肺癌 经外周置入中心静脉导管 血栓 危险因素 |
| 英文关键词:non-small cell lung cancer peripherally inserted central catheter thrombosis risk factors |
| 基金项目:中国癌症基金会北京希望马拉松专项基金（LC2021A05） |
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| 中文摘要: |
| 摘 要：［目的］探讨非小细胞肺癌（non-small cell lung cancer，NSCLC）患者发生经外周置入中心静脉导管相关上肢静脉血栓形成（peripherally inserted central catheter-related upper extremity venous thrombosis，PICC-UEVT）的危险因素。［方法］ 回顾性分析241例于中国医学科学院肿瘤医院行经外周静脉置入中心静脉导管(peripherally inserted central catheters，PICC) 辅助治疗的 NSCLC 患者的临床资料，采用二元 Logistic 回归分析可能影响 NSCLC 患者发生 PICC-UEVT 的危险因素，对单因素分析中差异有显著性的变量行多因素回归分析。［结果］ 58例（24.01%）患者发生 PICC-UEVT，症状性血栓和无症状性血栓分别为12例（20.69%）和46例（79.31%）。发生血栓的中位时间为19 d。多因素回归分析显示，男性（OR=4.220，95%CI：1.042~17.095）、经左上肢置管（OR=2.545，95%CI：1.271~5.097）、应用血管内皮生长因子（vascular endothelial growth factor，VEGF）抑制剂（OR=6.494，95%CI：2.780~15.171）以及胸部放疗（OR=3.825，95%CI：1.774~8.245）均显著性增加 PICC-UEVT 发生风险。［结论］ 男性、经左上肢置管、应用 VEGF 抑制剂以及胸部放疗是 NSCLC 患者发生 PICC-UEVT 的独立危险因素，需要临床医务人员引起高度重视，有助于早期预防和及时诊断 PICC-UEVT。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the risk factors of peripherally inserted central catheter-related upper extremity venous thrombosis(PICC-UEVT) in patients with non-small cell lung cancer(NSCLC). ［Methods］ Clinical data of 241 NSCLC patients with peripherally inserted central catheter(PICC) of Chinese Academy of Medical Sciences were reviewed retrospectively. The risk factors of PICC-UEVT in NSCLC patients were analyzed by binary Logistic regression. Multivariate regression analysis was performed to explore the correlations of variables with significant differences in univariate analysis. ［Results］ Among 241 patients PICC-UEVT developed in 58 cases(24.01%) ， including 12 symptomatic cases(20.69%) and 46 asymptomatic cases(79.31%). The median time of developing thrombosis was 19 d. Multivariate Logistic analysis showed that male gender（OR=4.220， 95% CI：1.042~17.095）， left-sided catheterization（OR=2.545， 95%CI：1.271~5.097）， anti-vascular endothelial growth factor（VEGF）therapy（OR=6.494， 95%CI：2.780~15.171） and chest radiotherapy（OR=3.825， 95%CI：1.774~8.245） were independent risk factors of PICC-UEVT. ［Conclusion］ Male gender， left-sided catheterization， anti-VEGF therapy and chest radiotherapy are independent risk factors for PICC-UEVT in NSCLC patients. Close attention should be paid to above risk factors for early prevention and timely diagnosis of PICC-UEVT. |
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