王 心,胡伟国,宋启斌.肥胖与乳腺癌发病相关性的研究进展[J].肿瘤学杂志,2021,27(12):986-990. |
肥胖与乳腺癌发病相关性的研究进展 |
Research Progress on the Correlation Between Obesity and Breast Cancer |
中文关键词 |
DOI:10.11735/j.issn.1671-170X.2021.12.B003 |
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中文关键词: 肥胖 乳腺肿瘤 发病率 体质指数 |
英文关键词:obesity breast cancer incidence rate body mass index |
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中文摘要: |
摘 要:肥胖通过多种分子机制影响乳腺癌的发生,包括胰岛素及胰岛素样生长因子、炎症细胞因子、瘦素及脂联素和雌激素的生理改变,但其影响因女性绝经状态不同而有所区别。大部分研究支持肥胖与绝经前乳腺癌风险呈负相关;而对于绝经后女性,肥胖会增加其罹患乳腺癌的风险。 |
英文摘要: |
Abstract: There are multiple molecular mechanisms linking obesity to the development of breast cancer, including systemic physiological changes of insulin, insulin-like growth factor, inflammatory cytokines, leptin, adiponectin and estrogen, and the influence vary with the menstrual state. Most studies support that obesity is negatively associated with premenopausal breast cancer risk, while for postmenopausal women, obesity increases the risk of breast cancer. |
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