| 李佳星,李 勇,王 姿.E2F1基因多态性与宫颈癌风险关联性研究[J].肿瘤学杂志,2021,27(11):952-955. |
| E2F1基因多态性与宫颈癌风险关联性研究 |
| Asssociation of E2F1 Gene Polymorphisms with Risk of Cervical Cancer |
| 投稿时间：2021-06-07 |
| DOI：10.11735/j.issn.1671-170X.2021.11.B010 |
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| 中文关键词: 宫颈癌 E2F1 基因多态性 发病风险 |
| 英文关键词:cervical cancer E2F1 gene polymorphism risk |
| 基金项目:贵州省科技厅项目（黔科合LH字【2015】7171），贵州省地方标准制修订项目计划（2019-89） |
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| 中文摘要: |
| 摘 要：［目的］ 选取E2F1基因中rs3213172、rs3213173和rs3213176三个多态性位点，研究其与宫颈癌的关联性。［方法］ 选取2016—2019年贵州省人民医院肿瘤科确诊为宫颈癌的149例患者为病例组，选取同期同院参加正常体检的健康女性206人为对照组。采用通用探针法对E2F1基因中的多态位点rs3213172、rs3213173和rs3213176进行基因分型，研究这些多态性位点的等位基因、基因型及构建的单倍型在对照组和病例组中分布频率的差异。［结果］ E2F1基因中的多态性位点rs3213172 CT基因型在病例组和对照组间分布频率差异有统计学意义，可能是宫颈癌发生的危险因素 (OR=1.57，95%CI：1.00～2.48)；多态位点rs3213173和rs321317的等位基因和基因型在病例组和对照组中的分布频率差异无统计学意义（P>0.05）。单倍型分型结果显示，rs3213172-rs3213173-rs3213176的单倍型C-T-G可能是宫颈癌发生的保护性因素（OR=0.66，95%CI：0.47～0.93）；单倍型T-T-G可能是宫颈癌发生的风险因素（OR=2.49，95%CI：1.35～4.59）。［结论］ E2F1基因中的多态位点rs3213172可能与宫颈癌的发病风险有关。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the association of the single nucleotide polymorphisms(SNPs) of E2F1 gene with risk of cervical cancer. ［Methods］ A total of 149 patients with cervical cancer admitted in Department of Oncology of Guizhou Provincial People’s Hospital from 2016 to 2019 were enrolled in the study， and 206 healthy women undergoing routine health check-up were recruited as control group. The rs3213172， rs3213173 and rs3213176 SNPs of E2F1 gene were examined with universal fluorescence probe assay. And the association between SNPs and the risk of cervical cancer was analyzed. ［Results］ There was significant difference in genotypic frequencies of rs3213172 between patients with cervical cancer and control groups， and CT genotypic might be an independent risk factor of cervical cancer(OR=1.57， 95%CI：1.00~2.48， P<0.05). However， the genotypic and allelic frequencies of rs3213173 and rs321317 showed no significant difference between cervical cancer patients and healthy controls. Additionally， the haplotype analysis showed that rs3213172-rs3213173-rs3213176 C-T-G haplotype occurred more frequent in control group compared to cervical cancer group(OR=0.66， 95CI%：0.47~0.93， P=0.02)， T-T-G haplotype might be associated with higher risk of cervical cancer(OR=2.49， 95%CI：1.35~4.59， P=0.02). ［Conclusion］ E2F1 gene polymorphisms may be associated with the risk of cervical cancer. |
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