| 徐力立,骆莹滨,吴建春.血清血脂水平与Ⅳ期非小细胞肺癌患者生存预后的相关性[J].肿瘤学杂志,2021,27(11):939-945. |
| 血清血脂水平与Ⅳ期非小细胞肺癌患者生存预后的相关性 |
| Correlation Between Serum Lipid Level and Prognosis of Patient of Non-small Cell Lung Cancer Stage Ⅳ |
| 投稿时间：2021-05-20 |
| DOI：10.11735/j.issn.1671-170X.2021.11.B008 |
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| 中文关键词: 非小细胞肺癌 总胆固醇 甘油三酯 高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 预后 |
| 英文关键词:non-small cell lung cancer total cholesterol triglyceride high density lipoprotein cholesterol low density lipoprotein cholesterol prognosis |
| 基金项目:国家自然科学基金面上项目（81973795）；上海申康医院发展中心临床三年行动计划（SHDC2020CR4052）；上海市浦江人才计划（2020PJD057）；上海中医药大学预算内项目（2019LK094） |
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| 中文摘要: |
| 摘 要：［目的］ 评估Ⅳ期NSCLC患者血清血脂水平与预后的关系，寻找Ⅳ期NSCLC预后的潜在因子。［方法］ 回顾性分析239例Ⅳ期NSCLC患者的临床资料，收集治疗前血清总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）和低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）水平。无进展生存期（progression free survival，PFS）和总生存期（overall survival，OS）是主要结局指标。用X-tile软件确定各个指标的最佳截断值，生存分析采用Kaplan-Meier法和Cox风险比例模型分析。［结果］ 与血脂低水平组相比，TC高值组（TC≥5.02 mmol/L）具有更好的PFS（P=0.021）和OS（P=0.001）。TG高值组（TG≥0.97 mmol/L）具有更好的OS（P=0.024）。HDL-C高值组（HDL-C≥1.19 mmol/L）具有更好的PFS（P＜0.001）和OS（P=0.024）。LDL-C高值组（LDL-C≥3.27 mmol/L）具有更好的OS（P=0.006）。Cox多因素回归分析表明，HDL-C是影响Ⅳ期NSCLC患者PFS（P=0.012）和OS（P=0.030）的独立预后因素。［结论］ 治疗前血清TC、TG、HDL-C和LDL-C水平可能是Ⅳ期NSCLC患者的重要预后因素。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between pretreatment serum lipid levels and prognosis in patients with stage Ⅳ non-small cell lung cancer(NSCLC). ［Methods］ The clinical data and blood lipids levels，including total cholesterol(TC)，triglyceride(TG)，high density lipoprotein cholesterol(HDL-C) and low density lipoprotein cholesterol(LDL-C) of 239 patients with stage Ⅳ NSCLC were retrospectively analyzed. The progression free survival(PFS) and overall survival(OS) of patients were calculated. The best cut-off value was determined by X-tile tool. For survival analysis，Kaplan-Meier method and Cox regression analysis were also used. ［Results］ Compared with patients with low lipid levels，patients with high TC levels(≥5.02 mmol/L) had better PFS(P=0.021) and OS(P=0.001)， patients with high TG levels(≥0.97 mmol/L) had better OS(P=0.024)， patients with high HDL-C levels(≥1.19 mmol/L) had better PFS(P＜0.001) and OS(P=0.024)， patients with high LDL-C levels(≥3.27 mmol/L) had better OS(P=0.006). Multivariate Cox regression analysis showed that HDL-C was an independent prognostic factor of PFS(P=0.012) and OS(P=0.030) in patients with stage Ⅳ NSCLC. ［Conclusion］ The pretreatment serum lipid levels including TC，TG，HDL-C and LDL-C can be significant prognostic factors for stage Ⅳ NSCLC. |
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