| 陈思维,欧阳湖,刘大权.改性聚酰胺-胺树枝状大分子用于肿瘤治疗的研究进展[J].肿瘤学杂志,2021,27(10):867-875. |
| 改性聚酰胺-胺树枝状大分子用于肿瘤治疗的研究进展 |
| Research Progress of Modified Polyamidoamine Dendrimers for Tumor Therapy |
| 投稿时间：2021-01-31 |
| DOI：10.11735/j.issn.1671-170X.2021.10.B013 |
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| 中文关键词: 改性聚酰胺-胺 改性方式 肿瘤治疗 载体 |
| 英文关键词:modified polyamidoamine modification methods tumor therapy carriers |
| 基金项目:2020年度湖南省教育厅科学研究重点项目（20A442） |
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| 中文摘要: |
| 摘 要：聚酰胺-胺（Polyamidoamine，PAMAM）树枝状大分子具有结构规整、高度枝化、反应活性良好的特点，广泛用作肿瘤靶向给药系统的载体。然而，由于PAMAM表面大量氨基导致其具有一定的毒性。研究者们采用表面工程化、靶向配体修饰、环境响应性基团修饰等多种修饰方式对PAMAM进行改性从而获得性能更加优良的改性聚酰胺-胺用于肿瘤治疗，取得了不错的效果。本文将对改性PAMAM树状大分子修饰改性方式以及其在肿瘤治疗中的应用研究现状与进展进行简要综述，以期为PAMAM在肿瘤治疗中更好应用提供参考。 |
| 英文摘要: |
| Abstract： Polyamidoamine(PAMAM) dendrimers have the characteristics of regular structure， high branching and good reactivity， which are widely used as carriers of tumor targeted drug delivery system. However， PAMAM has certain toxicity due to the large amount of amino groups on its surface. In order to obtain better performance modified polyamideamine for tumor treatment， The surface engineering， targeted ligand modification， environment responsive group modification and other modification methods have been applied to modify PAMAM and good progress have been achieved. In this article， the methods of modifying PAMAM dendrimers and their application in tumor therapy are briefly reviewed， to provide a reference for potential clinical use of PAMAM in tumor therapy. |
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