| 中文关键词: SLP-2 生理功能 信号通路 恶性肿瘤 |
| 英文关键词:SLP-2 physiological functions signal pathway malignant tumor |
| 基金项目:兰州大学第二医院“萃英学子科研培育”计划（CYXZ-12）；兰州市城关区科技计划项目（2019RCCX0034） |
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| 中文摘要: |
| 摘 要：SLP-2(stomatin-like protein 2)为近年来发现的Stomatin超家族的新成员。研究发现，SLP-2参与多种恶性肿瘤的发生发展，有望成为多种肿瘤早期筛查、靶向治疗以及预后评估的肿瘤标志物。全文从SLP-2结构功能、肿瘤表型、信号通路和临床转化等方面探讨SLP-2在肿瘤领域的研究进展，旨在探讨SLP-2的潜在临床价值。 |
| 英文摘要: |
| Abstract： Stomatin-like protein-2(SLP-2) has been discovered as a new member of the Stomatin superfamily in recent years. Studies have found that SLP-2 is involved in the development and progression of a variety of malignant tumors， which is expected to be a novel diagnostic marker， therapeutic target and prognosis factor for cancers. In this review， the research advances of SLP-2 in tumors are discussed from the aspects of SLP-2 structure and function， roles of SLP-2 in tumor phenotype， SLP-2-related signal pathway， and preliminary translational attempts， aiming to explore its potential clinical application. |
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