| 张昊晗,赵亚琪,武 杰.RAS相关蛋白1b在肿瘤中调控机制的研究进展[J].肿瘤学杂志,2021,27(8):661-666. |
| RAS相关蛋白1b在肿瘤中调控机制的研究进展 |
| Research Progress on the Regulating Mechanism of RAS-associated Protein 1b in Tumor |
| 投稿时间：2020-12-07 |
| DOI：10.11735/j.issn.1671-170X.2021.08.B010 |
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| 中文关键词: Rap1b 肿瘤 信号通路 |
| 英文关键词:Rap1b tumor signaling pathway |
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| 摘要点击次数: 901 |
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| 中文摘要: |
| 摘 要：Ras相关蛋白1（RAS -associated protein 1，Rap1）是RAS家族小G蛋白中的一员，可通过多种信号通路参与癌变过程。Rap1由两种高度同源异构体Rap1a和Rap1b组成，其中Rap1b通过参与Wnt/β-catenin、PI3K/Akt/mTOR、NF-κB/Twist1、cAMP/PKA等多种通路，在调节细胞增殖、转移，血管生成，免疫逃逸等与肿瘤发生发展相关的方面有显著调控作用。根据其调控作用，Rap1b可能作为肿瘤治疗靶点，通过靶向Rap1b的治疗可能抑制肿瘤的转移、血管生成，解除免疫抑制，减缓耐药。全文就Rap1b对肿瘤相关细胞及通路调节作用的研究进展作一综述。 |
| 英文摘要: |
| Abstract： Ras-associated protein 1(Rap1) is a member of the small G proteins of the RAS family， and it participates in the process of carcinogenesis through multiple signaling pathways. Rap1 is composed of two highly homologous isomers：Rap1a and Rap1b. Rap1b is involved in the cell proliferation and metastasis， angiogenesis， immune escape， and other aspects related to tumor occurrence and development， through regulating Wnt/β-catenin， PI3K/Akt/mTOR， NF-κB/Twist1， cAMP/PKA， and other signaling pathways. It is suggested that Rap1b may be used as a tumor treatment target to inhibit tumor metastasis and angiogenesis， relieve immunosuppression， and slow down the emergence of drug resistance. Here we review the research progress of Rap1b in regulating tumor-related cells and involved signaling pathways. |
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