| 蔡秋莉,陈 芸,蔡昕怡.结直肠腺癌中CD163+巨噬细胞、CD8+T细胞与微血管密度的相关性[J].肿瘤学杂志,2021,27(8):622-627. |
| 结直肠腺癌中CD163+巨噬细胞、CD8+T细胞与微血管密度的相关性 |
| Relationship Among CD163+ Macrophage， CD8+ T Cell， Microvessel Density and Clinicopathological Features in Patients with Colorectal Adenocarcinoma |
| 投稿时间：2021-05-20 |
| DOI：10.11735/j.issn.1671-170X.2021.08.B004 |
|
 |
| 中文关键词: 结直肠肿瘤 肿瘤相关巨噬细胞 CD8+T细胞 血管生成 |
| 英文关键词:colorectal cancer tumor-associated macrophages CD8+T cells angiogenesis |
| 基金项目:云南省科技厅昆明医科大学应用基础研究联合专项（2017FE468-070） |
|
| 摘要点击次数: 925 |
| 全文下载次数: 272 |
| 中文摘要: |
| 摘 要：［目的］ 探讨结直肠腺癌中CD163+巨噬细胞、CD8+T细胞、微血管密度（MVD）的相关性及与患者临床病理因素的关系。［方法］ 通过免疫组化SP法检测61例结直肠腺癌癌组织及远癌组织中CD163+巨噬细胞、CD8+T细胞、CD34的表达水平，分析 CD163+巨噬细胞、CD8+T细胞、MVD的相关性及与患者临床病理因素的关系。［结果］ CD163、CD8、MVD在癌组织及远癌组织中的表达差异具有统计学意义(P均<0.001)。CD163与MVD的表达具有显著正相关性(r=0.615，P<0.001)，CD8与MVD的表达具有负相关性(r=-0.320，P=0.012)，CD8与CD163的表达具有显著负相关性(r=-0.370，P=0.003)。CD163+巨噬细胞与结直肠腺癌分化程度、淋巴结转移、远处转移、TNM分期相关（P<0.05），MVD与结直肠腺癌肿瘤位置、分化程度、淋巴结转移、远处转移、TNM分期相关（P<0.05），CD8+T细胞与患者性别、年龄、肿瘤位置、分化程度、TNM分期、淋巴转移、远处转移均无关（P>0.05）。［结论］ 联合靶向消除TAMs及促进CD8+T细胞的活化与增殖可能对结直肠癌的抗血管生成治疗有一定意义。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the relationship among CD163+ macrophage， CD8+ T cell， microvessel density (MVD) and clinicopathological features in patients with colorectal adenocarcinoma. ［Methods］ The expression of CD163+ macrophage， CD8+ T cells， and CD34 in 61 colorectal adenocarcinoma cancer tissues and distant cancer tissues were detected by immunohistochemical SP method. The relationship among CD163+ macrophage， CD8+ T cells， MVD and clinicopathological features of patients were analyzed. ［Results］ The expressions of CD163， CD8 and MVD were significantly different between cancer tissues and distant cancer tissues(all P<0.001). CD163 was positively correlated with MVD(r=0.615， P<0.001)， CD8 was negatively correlated with MVD(r=-0.320， P=0.012)， and CD8 was significantly negatively correlated with the expression of CD163(r=-0.370， P=0.003). CD163+ was correlated with the degree of differentiation， lymphatic metastasis， distant metastasis， and TNM stage of colorectal adenocarcinoma(P<0.05). MVD was correlated with the location， degree of differentiation， lymphatic metastasis， distant metastasis， and TNM stage(P<0.05). CD8+ T was not corrected with gender， age， tumor location， differentiation degree， TNM stage， lymphatic metastasis， and distant metastasis in(P>0.05). ［Conclusion］ The study indicates that combined targeted elimination of tumor associated macrophages and promotion of CD8+ T cell activation and proliferation may have an effect on anti-angiogenic therapy for colorectal cancer. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |