| 苏 航,张 岱,任伟宏.外泌体蛋白相关肿瘤标志物研究进展[J].肿瘤学杂志,2021,27(6):487-493. |
| 外泌体蛋白相关肿瘤标志物研究进展 |
| Research Progress of Exosome Protein-related Tumor Markers |
| 投稿时间：2020-08-29 |
| DOI：10.11735/j.issn.1671-170X.2021.06.B013 |
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| 中文关键词: 外泌体蛋白 肿瘤标志物 早期诊断 |
| 英文关键词:exosomal protein tumor marker early diagnosis |
| 基金项目:河南省高等学校重点科研项目计划（19zx009） |
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| 中文摘要: |
| 摘 要：肿瘤早期诊断是其预防和治疗的关键，有效的肿瘤标志物是肿瘤早期诊断的重要手段之一。肿瘤细胞能够分泌外泌体（exosomes），其在电镜下呈杯状，直径30～150 nm，被脂质双分子层包围，广泛存在于各种体液中。外泌体内容物包括蛋白质、短肽链、脂质、核苷酸等，其中外泌体蛋白可作为潜在的肿瘤诊断标志物。与活体组织样本检测相比，外泌体蛋白检测具有取样快速简便、检测成本低等优势，在肿瘤诊断中具有广阔的发展前景。全文就肿瘤外泌体差异蛋白变化及其在肿瘤诊断方面的研究进行综述。 |
| 英文摘要: |
| Abstract：Early diagnosis is the key issue for cancer prevention and treatment，and effective tumor markers are one of the important means leading to early diagnosis. Tumor cells can secrete exosomes，which are cup-shaped under electron microscope，with a diameter of 30～150 nm，surrounded by lipid bilayer，and widely exist in various body fluids. Exosomes include proteins，short peptide chains，lipids，nucleotides and other biological molecules. Exosomes can be used as potential tumor diagnostic markers. Compared with the detection of living tissue samples，detection of exosome proteins has the advantages of rapid sampling，low cost and so on，which has a promissing prospect in tumor diagnosis. In this article the changes of tumor exosome differential proteins and their application in tumor diagnosis are reviewed. |
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