| 中文关键词: 肿瘤血管生成 miRNA 细胞外囊泡 |
| 英文关键词:tumor angiogenesis miRNA extracellular vesicle |
| 基金项目:国家自然科学基金青年项目（81802693） |
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| 中文摘要: |
| 摘 要：肿瘤血管生成在肿瘤的生长和转移过程中发挥重要的作用。微小RNA（microRNA，miRNA）是一类内源性单链非编码RNA分子，通过转录后水平调控广泛参与肿瘤相关生物学过程。MiRNA通过调控促血管生成因子、血管生成抑制因子及血管生成相关信号通路来促进或抑制肿瘤血管生成，并介导肿瘤细胞和血管内皮细胞间细胞通讯。全文对miRNA在肿瘤血管生成中的调控作用进行总结，并对miRNA作为抗肿瘤血管生成新的治疗手段及抗血管生成治疗效果生物标志物的临床意义进行讨论。 |
| 英文摘要: |
| Abstract：Angiogenesis is essential for tumor growth and metastasis. MicroRNAs(miRNAs) are single stranded，non-coding RNA molecules generated endogenously that function in diverse biological processes via post-transcriptional regulation. miRNA promotes or inhibits tumor angiogenesis by regulating pro-angiogenesis factors，angiogenesis inhibitors and angiogenesis-related signaling pathways. In addition，miRNA mediates intercellular communication between tumor cells and vascular endothelial cells. In this review，the regulatory roles of miRNA in tumor angiogenesis are summarized，and clinical implications of miRNAs as therapeutic interventions against tumor angiogenesis and as biomarkers for response of anti-angiogenic therapy are discussed. |
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