范立侨,夏宇翔,檀碧波.苹果酸舒尼替尼二线治疗37例晚期胃肠间质瘤的临床研究[J].肿瘤学杂志,2021,27(6):455-458. |
苹果酸舒尼替尼二线治疗37例晚期胃肠间质瘤的临床研究 |
Sunitinib Malate as Second-line Therapy for Advanced Gastrointestinal Stromal Tumor:An Analysis of 37 Cases |
投稿时间:2021-02-22 |
DOI:10.11735/j.issn.1671-170X.2021.06.B008 |
|
|
中文关键词: 胃肠间质瘤 苹果酸舒尼替尼 无进展生存期 总生存期 不良反应 |
英文关键词:gastrointestinal stromal tumor sunitinib malate PFS OS adverse reactions |
基金项目:河北省科技厅课题(14277751D) |
|
摘要点击次数: 1115 |
全文下载次数: 269 |
中文摘要: |
摘 要:[目的] 探讨苹果酸舒尼替尼二线治疗晚期胃肠间质瘤(GIST)患者的临床疗效及其不良反应。[方法] 选取河北医科大学第四医院应用苹果酸舒尼替尼二线治疗的37例晚期胃肠间质瘤患者的临床资料,进行回顾性分析,按Choi标准进行疗效评估。[结果] 37例患者共接受苹果酸舒尼替尼治疗701个月,平均18.9个月。治疗后PR 4例(10.8%)、SD 17例(45.9%)、PD 16例(32.4%),总体客观有效率(ORR)为10.8%,疾病控制率(DCR)为56.8%。不良反应多为1~2级,3~4级较少,无5级不良反应。肝转移组中位无进展生存期(PFS)为18.0个月,较腹腔转移组(8.5个月)明显增加(P<0.05);c-kit外显子11突变组PFS为14.0个月,较外显子9突变组(15.0个月)降低(P<0.05)。[结论] 苹果酸舒尼替尼二线治疗GIST可提高DCR,延长PFS,其对单纯肝转移者及c-kit 9外显子突变者疗效更加显著,不良反应可耐受。 |
英文摘要: |
Abstract:[Objective] To investigate the clinical efficacy and safety of sunitinib malate as second-line therapy for patients with advanced gastrointestinal stromal tumor(GIST). [Methods] The clinical data of 37 patients with advanced GIST treated with sunitinib malate as second-line therapy in the Fourth Hospital of Hebei Medical University from January 2003 to December 2018 were retrospectively analyzed. The efficacy was evaluated according to Choi standard. [Results] Patients received the treatment of sunitinib malate with an average of 18.9 months. There were 4 cases of PR(10.8%),17 cases of SD(45.9%) and 16 cases of PD(32.4%). The overall objective response rate(ORR) was 10.8%,and the disease control rate(DCR) was 56.8%. The adverse drug reactions were mostly grade 1~2,and no grade 5 adverse drug reactions was observed. The PFS of liver metastasis group was significantly higher than that of abdominal metastasis group(18.0 months vs 8.5 months,P<0.05);the PFS of c-kit exon 11 mutation group was lower than that of exon 9 mutation group(14.0 months vs 15.0 months,P<0.05). [Conclusion] Sunitinib malate may improve DCR and prolong PFS in patients with advanced GSIT. The curative effect is more significant in patients with simple liver metastasis and c-kit exon 9 mutation,and adverse reactions are tolerable. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |